Development of angiotensin II-induced abdominal aortic aneurysms is independent of Catalase in mice

Haruhito Adam Uchida, Hitoshi Sugiyama, Keiichi Takiue, Yoko Kikumoto, Tatsuyuki Inoue, Hirofumi Makino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chronic infusion of angiotensin II (AngII) into mice augments the development of abdominal aortic aneurysms (AAAs). Catalase is an important antioxidant enzyme in cellular peroxisome, and it physiologically maintains tissue and cellular redox homeostasis and thus plays a central role in defense against oxidative stress. The purpose of this study was to define whether deficiency of catalase influences AngII-induced AAAs. Male acatalasemic (C3H/AnLCs bCs b) mice and wild-type (C3H/AnLCs aCs a) mice (8-12 weeks old, N = 24 and 25, respectively) were fed a normal chow for 5 weeks. After 1 week of acclimtion, mice were infused subcutaneously with AngII (1000 ng•kg -1•min -1) by osmotic minipumps for 4 weeks. AngII increased systolic blood pressure equivalently in both groups. Acatalasemia had no effect on serum cholesterol concentrations. The body weight of acatalasemic mice was slightly greater than that of wild-type mice (P = 0.008). Although aortic catalase activity in acatalasemic mice was significantly low (P <0.001), acatalasemia had no significant effect on the incidence of AngII-induced AAA formation (acatalasemia, 23%; wild, 21%), ex vivo measurement of maximal diameter of abdominal aorta (acatalasemia, 1.22 ± 0.29 mm; wild, 1.21 ± 0.17 mm), or aortic deposition of lipid peroxidation products such as 4-hydroxy-2-nonenal. The development of AngII-induced AAAs is independent of catalase.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume58
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Acatalasia
Abdominal Aortic Aneurysm
Angiotensin II
Catalase
Blood Pressure
Peroxisomes
Inbred C3H Mouse
Abdominal Aorta
Lipid Peroxidation
Oxidation-Reduction
Oxidative Stress
Homeostasis
Antioxidants
Cholesterol
Body Weight
Incidence
Enzymes
Serum

Keywords

  • aneurysms
  • angiotensin II
  • catalase

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Development of angiotensin II-induced abdominal aortic aneurysms is independent of Catalase in mice. / Uchida, Haruhito Adam; Sugiyama, Hitoshi; Takiue, Keiichi; Kikumoto, Yoko; Inoue, Tatsuyuki; Makino, Hirofumi.

In: Journal of Cardiovascular Pharmacology, Vol. 58, No. 6, 12.2011, p. 633-638.

Research output: Contribution to journalArticle

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