Abstract
The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 729-731 |
| Number of pages | 3 |
| Journal | ASAIO Transactions |
| Volume | 34 |
| Issue number | 3 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Biophysics
Cite this
Development of an interleukin-2 slow delivery system. / Matsuoka, Junji; Sakagami, K.; Shiozaki, S.; Uchida, S.; Fujiwara, Toshiyoshi; Gohchi, A.; Orita, K.
In: ASAIO Transactions, Vol. 34, No. 3, 1988, p. 729-731.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of an interleukin-2 slow delivery system
AU - Matsuoka, Junji
AU - Sakagami, K.
AU - Shiozaki, S.
AU - Uchida, S.
AU - Fujiwara, Toshiyoshi
AU - Gohchi, A.
AU - Orita, K.
PY - 1988
Y1 - 1988
N2 - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.
AB - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023698898&partnerID=8YFLogxK
M3 - Article
VL - 34
SP - 729
EP - 731
JO - ASAIO Journal
JF - ASAIO Journal
SN - 1058-2916
IS - 3
ER -