Development of an interleukin-2 slow delivery system

Junji Matsuoka, K. Sakagami, S. Shiozaki, S. Uchida, Toshiyoshi Fujiwara, A. Gohchi, K. Orita

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

Original languageEnglish
Pages (from-to)729-731
Number of pages3
JournalASAIO Transactions
Volume34
Issue number3
Publication statusPublished - 1988

Fingerprint

Collagen
Interleukin-2
Pharmacokinetics
Needles
Subcutaneous Injections
Experiments
Interleukin-1
Inbred C57BL Mouse
Intravenous Injections
Half-Life
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biophysics

Cite this

Matsuoka, J., Sakagami, K., Shiozaki, S., Uchida, S., Fujiwara, T., Gohchi, A., & Orita, K. (1988). Development of an interleukin-2 slow delivery system. ASAIO Transactions, 34(3), 729-731.

Development of an interleukin-2 slow delivery system. / Matsuoka, Junji; Sakagami, K.; Shiozaki, S.; Uchida, S.; Fujiwara, Toshiyoshi; Gohchi, A.; Orita, K.

In: ASAIO Transactions, Vol. 34, No. 3, 1988, p. 729-731.

Research output: Contribution to journalArticle

Matsuoka, J, Sakagami, K, Shiozaki, S, Uchida, S, Fujiwara, T, Gohchi, A & Orita, K 1988, 'Development of an interleukin-2 slow delivery system', ASAIO Transactions, vol. 34, no. 3, pp. 729-731.
Matsuoka J, Sakagami K, Shiozaki S, Uchida S, Fujiwara T, Gohchi A et al. Development of an interleukin-2 slow delivery system. ASAIO Transactions. 1988;34(3):729-731.
Matsuoka, Junji ; Sakagami, K. ; Shiozaki, S. ; Uchida, S. ; Fujiwara, Toshiyoshi ; Gohchi, A. ; Orita, K. / Development of an interleukin-2 slow delivery system. In: ASAIO Transactions. 1988 ; Vol. 34, No. 3. pp. 729-731.
@article{253a910634cc4472b2474520f74691f3,
title = "Development of an interleukin-2 slow delivery system",
abstract = "The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.",
author = "Junji Matsuoka and K. Sakagami and S. Shiozaki and S. Uchida and Toshiyoshi Fujiwara and A. Gohchi and K. Orita",
year = "1988",
language = "English",
volume = "34",
pages = "729--731",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Development of an interleukin-2 slow delivery system

AU - Matsuoka, Junji

AU - Sakagami, K.

AU - Shiozaki, S.

AU - Uchida, S.

AU - Fujiwara, Toshiyoshi

AU - Gohchi, A.

AU - Orita, K.

PY - 1988

Y1 - 1988

N2 - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

AB - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

UR - http://www.scopus.com/inward/record.url?scp=0023698898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023698898&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 729

EP - 731

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 3

ER -