Development of an interleukin-2 slow delivery system

J. Matsuoka, K. Sakagami, S. Shiozaki, S. Uchida, T. Fujiwara, A. Gohchi, K. Orita

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Abstract

The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

Original languageEnglish
Pages (from-to)729-731
Number of pages3
JournalASAIO Transactions
Volume34
Issue number3
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Biophysics

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    Matsuoka, J., Sakagami, K., Shiozaki, S., Uchida, S., Fujiwara, T., Gohchi, A., & Orita, K. (1988). Development of an interleukin-2 slow delivery system. ASAIO Transactions, 34(3), 729-731.