Development of an interleukin-2 slow delivery system

J. Matsuoka; K. Sakagami; S. Shiozaki; S. Uchida; T. Fujiwara; A. Gohchi; K. Orita

Development of an interleukin-2 slow delivery system

J. Matsuoka, K. Sakagami, S. Shiozaki, S. Uchida, T. Fujiwara, A. Gohchi, K. Orita

Research output: Contribution to journal › Article › peer-review

Abstract

The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 10⁶ μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

Original language	English
Pages (from-to)	729-731
Number of pages	3
Journal	ASAIO Transactions
Volume	34
Issue number	3
Publication status	Published - Jan 1 1988

ASJC Scopus subject areas

Biophysics

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AU - Matsuoka, J.

AU - Sakagami, K.

AU - Shiozaki, S.

AU - Uchida, S.

AU - Fujiwara, T.

AU - Gohchi, A.

AU - Orita, K.

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N2 - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

AB - The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effect of IL-2; 1 x 106 μm of recombinant human IL-2 was successfully infused into needle-shaped 'IL-2 mini-pellets'. Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 minipellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.

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Development of an interleukin-2 slow delivery system

Abstract

ASJC Scopus subject areas

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