Development of an active targeting liposome encapsulated with high-density colloidal gold for transmission electron microscopy

Hideki Minematsu, Takayuki Otani, Toshitaka Oohashi, Masahiko Hirai, Kazunori Oie, Koichi Igarashi, Aiji Ohtsuka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Active targeting of the liposome is an attractive strategy for drug delivery and in vivo bio-imaging. We previously reported the specific accumulation of Sialyl Lewis X (SLX) liposome to inflamed tissue in arthritic model mice or tumor-bearing mice. SLX-liposome encapsulation with fluorescent substances allows for the visualization of these liposomes by the time-dependent transvascular accumulation of fluorescent signals in the histological sections. In the present study, we developed a new SLX-liposome encapsulated with colloidal gold for transmission electron microscopic observation. We herein describe the characterization of the colloidal gold-loaded SLX-liposomes and demonstrate its specific targeting to the endothelial cells of tumor blood vessels in tumor-bearing mice.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalJournal of Electron Microscopy
Volume60
Issue number1
DOIs
Publication statusPublished - Feb 1 2011

Keywords

  • active targeting liposome
  • arthritis
  • colloidal gold
  • drug delivery
  • electron microscopy
  • tumor

ASJC Scopus subject areas

  • Instrumentation

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