Development of a simple spasticity quantification method: Effects of tizanidine on spasticity in patients with-Sequelae of cerebrovascular disease

N. Ogawa, Masato Asanuma, H. Hirata, Z. Ota, Y. Yamawaki, M. Yamamoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A simple method that can be performed at the bedside using a spring balance was developed in order to quantify spasticity. The effects of tizanidine on spasticity were evaluated in 30 patients with sequelae of cerebrovascular disease using this method. Treatment with tizanidine was effective in 60% of the patients; there were high correlations between spasticity before and after tizanidine administration and the severity of symptoms and also between the degree of improvement in spasticity and in that of the symptoms. Atonic seizures, due to overdose of tizanidne, were observed in only one patient. The simple spasticity quantification method developed was useful for monitoring tizanidine administration in order to prevent drug overdose. The method appears to be very useful for evaluating the degree of spasticity at the bedside and in measuring the effects of antispastic drugs.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalJournal of International Medical Research
Volume20
Issue number1
Publication statusPublished - 1992

Fingerprint

Cerebrovascular Disorders
Drug Overdose
Pharmaceutical Preparations
Seizures
tizanidine
Monitoring
Therapeutics

Keywords

  • Antispastic drug
  • Hemiplegia
  • Tizanidine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Development of a simple spasticity quantification method : Effects of tizanidine on spasticity in patients with-Sequelae of cerebrovascular disease. / Ogawa, N.; Asanuma, Masato; Hirata, H.; Ota, Z.; Yamawaki, Y.; Yamamoto, M.

In: Journal of International Medical Research, Vol. 20, No. 1, 1992, p. 78-86.

Research output: Contribution to journalArticle

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