Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values

Yuuki Yoshimura, Masahiro Kuroda, Irfan Sugianto, Abdullah Khasawneh, Babatunde O. Bamgbose, Kentaro Hamada, Majd Barham, Nouha Tekiki, Akira Kurozumi, Toshi Matsushita, Seiichiro Ohno, Susumu Kanazawa, Junichi Asaumi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In order to visualize restricted diffusion, the present study developed a novel method called 'apparent diffusion coefficient (ADC) subtraction method (ASM)' and compared it with diffusion kurtosis imaging (DKI). The diffusion-weighted images of physiological saline, in addtion to bio-phatoms of low cell density and the highest cell density were obtained using two sequences with different effective diffusion times. Then, the calculated ADC values were subtracted. The mean values and standard deviations (SD) of the ADC values of physiological saline, low cell density and the highest cell density phantoms were 2.95±0.08x10⁻³, 1.90±0.35×10⁻³ and 0.79±0.05×10⁻³ mm²/sec, respectively. The mean kurtosis values and SD of DKI were 0.04±0.01, 0.44±0.13 and 1.27±0.03, respectively. The ASM and SD values were 0.25±0.20×10⁴, 0.51±0.41×10⁴ and 4.80±4.51×10⁴ (sec/mm²)², respectively. Using bio-phantoms, the present study demonstrated that DKI exhibits restricted diffusion in the extracellular space. Similarly, ASM may reflect the extent of restricted diffusion in the extracellular space.

Original languageEnglish
Pages (from-to)2963-2969
Number of pages7
JournalMolecular Medicine Reports
Volume20
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • Apparent diffusion coefficient
  • Bio-phantom
  • Cell
  • Diffusion kurtosis imaging
  • Magnetic resonance imaging
  • Restricted diffusion
  • Subtraction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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