TY - JOUR
T1 - Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values
AU - Yoshimura, Yuuki
AU - Kuroda, Masahiro
AU - Sugianto, Irfan
AU - Khasawneh, Abdullah
AU - Bamgbose, Babatunde O.
AU - Hamada, Kentaro
AU - Barham, Majd
AU - Tekiki, Nouha
AU - Kurozumi, Akira
AU - Matsushita, Toshi
AU - Ohno, Seiichiro
AU - Kanazawa, Susumu
AU - Asaumi, Junichi
N1 - Publisher Copyright:
© 2019 Spandidos Publications. All rights reserved.
PY - 2019
Y1 - 2019
N2 - In order to visualize restricted diffusion, the present study developed a novel method called 'apparent diffusion coefficient (ADC) subtraction method (ASM)' and compared it with diffusion kurtosis imaging (DKI). The diffusion-weighted images of physiological saline, in addtion to bio-phatoms of low cell density and the highest cell density were obtained using two sequences with different effective diffusion times. Then, the calculated ADC values were subtracted. The mean values and standard deviations (SD) of the ADC values of physiological saline, low cell density and the highest cell density phantoms were 2.95±0.08x10⁻³, 1.90±0.35×10⁻³ and 0.79±0.05×10⁻³ mm²/sec, respectively. The mean kurtosis values and SD of DKI were 0.04±0.01, 0.44±0.13 and 1.27±0.03, respectively. The ASM and SD values were 0.25±0.20×10⁴, 0.51±0.41×10⁴ and 4.80±4.51×10⁴ (sec/mm²)², respectively. Using bio-phantoms, the present study demonstrated that DKI exhibits restricted diffusion in the extracellular space. Similarly, ASM may reflect the extent of restricted diffusion in the extracellular space.
AB - In order to visualize restricted diffusion, the present study developed a novel method called 'apparent diffusion coefficient (ADC) subtraction method (ASM)' and compared it with diffusion kurtosis imaging (DKI). The diffusion-weighted images of physiological saline, in addtion to bio-phatoms of low cell density and the highest cell density were obtained using two sequences with different effective diffusion times. Then, the calculated ADC values were subtracted. The mean values and standard deviations (SD) of the ADC values of physiological saline, low cell density and the highest cell density phantoms were 2.95±0.08x10⁻³, 1.90±0.35×10⁻³ and 0.79±0.05×10⁻³ mm²/sec, respectively. The mean kurtosis values and SD of DKI were 0.04±0.01, 0.44±0.13 and 1.27±0.03, respectively. The ASM and SD values were 0.25±0.20×10⁴, 0.51±0.41×10⁴ and 4.80±4.51×10⁴ (sec/mm²)², respectively. Using bio-phantoms, the present study demonstrated that DKI exhibits restricted diffusion in the extracellular space. Similarly, ASM may reflect the extent of restricted diffusion in the extracellular space.
KW - Apparent diffusion coefficient
KW - Bio-phantom
KW - Cell
KW - Diffusion kurtosis imaging
KW - Magnetic resonance imaging
KW - Restricted diffusion
KW - Subtraction
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U2 - 10.3892/mmr.2019.10523
DO - 10.3892/mmr.2019.10523
M3 - Article
C2 - 31524240
AN - SCOPUS:85070390456
VL - 20
SP - 2963
EP - 2969
JO - Molecular Medicine Reports
JF - Molecular Medicine Reports
SN - 1791-2997
IS - 3
ER -