Development of a novel inducer of protein-protein interactions based on aplyronine A

Takayuki Ohyoshi, Atsuhiro Takano, Mayu Namiki, Tomotaka Ogura, Yuto Miyazaki, Yuta Ebihara, Koichi Takeno, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Original languageEnglish
Pages (from-to)9537-9540
Number of pages4
JournalChemical Communications
Volume54
Issue number68
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Development of a novel inducer of protein-protein interactions based on aplyronine A'. Together they form a unique fingerprint.

  • Cite this

    Ohyoshi, T., Takano, A., Namiki, M., Ogura, T., Miyazaki, Y., Ebihara, Y., Takeno, K., Hayakawa, I., & Kigoshi, H. (2018). Development of a novel inducer of protein-protein interactions based on aplyronine A. Chemical Communications, 54(68), 9537-9540. https://doi.org/10.1039/c8cc04613a