Development of a novel inducer of protein-protein interactions based on aplyronine A

Takayuki Ohyoshi, Atsuhiro Takano, Mayu Namiki, Tomotaka Ogura, Yuto Miyazaki, Yuta Ebihara, Koichi Takeno, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Original languageEnglish
Pages (from-to)9537-9540
Number of pages4
JournalChemical Communications
Volume54
Issue number68
DOIs
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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