Development of a novel inducer of protein-protein interactions based on aplyronine A

Takayuki Ohyoshi, Atsuhiro Takano, Mayu Namiki, Tomotaka Ogura, Yuto Miyazaki, Yuta Ebihara, Koichi Takeno, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Original languageEnglish
Pages (from-to)9537-9540
Number of pages4
JournalChemical Communications
Volume54
Issue number68
DOIs
Publication statusPublished - Jan 1 2018

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Proteins
Actins
Cytotoxicity
Bioactivity
Tubulin
aplyronine A
swinholide A

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Ohyoshi, T., Takano, A., Namiki, M., Ogura, T., Miyazaki, Y., Ebihara, Y., ... Kigoshi, H. (2018). Development of a novel inducer of protein-protein interactions based on aplyronine A. Chemical Communications, 54(68), 9537-9540. https://doi.org/10.1039/c8cc04613a

Development of a novel inducer of protein-protein interactions based on aplyronine A. / Ohyoshi, Takayuki; Takano, Atsuhiro; Namiki, Mayu; Ogura, Tomotaka; Miyazaki, Yuto; Ebihara, Yuta; Takeno, Koichi; Hayakawa, Ichiro; Kigoshi, Hideo.

In: Chemical Communications, Vol. 54, No. 68, 01.01.2018, p. 9537-9540.

Research output: Contribution to journalArticle

Ohyoshi, T, Takano, A, Namiki, M, Ogura, T, Miyazaki, Y, Ebihara, Y, Takeno, K, Hayakawa, I & Kigoshi, H 2018, 'Development of a novel inducer of protein-protein interactions based on aplyronine A', Chemical Communications, vol. 54, no. 68, pp. 9537-9540. https://doi.org/10.1039/c8cc04613a
Ohyoshi T, Takano A, Namiki M, Ogura T, Miyazaki Y, Ebihara Y et al. Development of a novel inducer of protein-protein interactions based on aplyronine A. Chemical Communications. 2018 Jan 1;54(68):9537-9540. https://doi.org/10.1039/c8cc04613a
Ohyoshi, Takayuki ; Takano, Atsuhiro ; Namiki, Mayu ; Ogura, Tomotaka ; Miyazaki, Yuto ; Ebihara, Yuta ; Takeno, Koichi ; Hayakawa, Ichiro ; Kigoshi, Hideo. / Development of a novel inducer of protein-protein interactions based on aplyronine A. In: Chemical Communications. 2018 ; Vol. 54, No. 68. pp. 9537-9540.
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