Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft

T. Pinelli, S. Altieri, F. Fossati, A. Zonta, U. Prati, L. Roveda, R. Nano

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

We present results on surgical technique, neutron field and irradiation facility concerning the original treatment of the liver diffused metastases. Our method plans to irradiate the isolated organ at a thermal neutron field soon after having been explanted and boron enriched and before being grafted into the same donor (liver autograft with boron neutron capture therapy). In particular the crucial point of boron uptake was investigated by a rat model with a relevant number of procedure (65). We give for the first time statistically significant results on the selective boron absorption by tumour tissues. The data reported in section 6 evidence an important progress on the way of the clinical application of the procedure.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2867
DOIs
Publication statusPublished - Feb 27 1996
Externally publishedYes
EventInternational Conference Neutrons in Research and Industry 1996 - Crete, Greece
Duration: Jun 9 1996Jun 15 1996

Keywords

  • Autograft
  • Boron uptake
  • Liver metastases
  • Neutron capture therapy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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