An octopus arm is boneless and mostly composed of muscles placed in the various directions around the nerve. The muscle is placed in three directions mainly, the octopus arm can perform multiple functions such as the contracting, bending, torsion, and stiffness change by driving the muscles selectively. We have developed a flexible manipulator using thin McKibben actuators by imitating the structure of the octopus arm. Various movements are possible by driving artificial muscles. However stiffness change of the manipulator is not enough. On the other hand, the mechanism with variable stiffness is achieved by using granular jamming. In this paper, we add granular jamming mechanism to the flexible manipulator for aiming widely stiffness change. First, to understand an effect by granular jamming, the cylindrical rubber including particles is configured and tested. Next the flexible manipulator with variable stiffness function is fabricated using this cylinder and the artificial muscles. Moreover, we make a multistage flexible manipulator.