Development and prospects of organ replacement regenerative therapy

Masatoshi Hirayama, Masamitsu Oshima, Takashi Tsuji

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Current approaches for the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs to replace lost or damaged organs that result from disease, injury, or aging. Almost all organs including ectodermal organs, such as teeth, hair, salivary glands, and lacrimal glands, arise from organ germs induced by reciprocal epithelial-mesenchymal interactions in the developing embryo. A novel concept to generate a bioengineered organ is to recreate organogenesis and thereby develop fully functioning bioengineered organs from the resulting bioengineered organ germ generated via 3-dimensional cell manipulation using immature stem cells in vitro. We have previously developed a bioengineering method for forming a 3-dimensional organ germ in the early developmental stages, termed the "bioengineered organ germ method." Recently, we reported fully functioning bioengineered tooth replacements after transplantation of a bioengineered tooth germ or a mature tooth unit comprising the bioengineered tooth and periodontal tissues. This concept could be adopted to generate not only teeth but also bioengineered hair follicles, salivary glands, and lacrimal glands. These studies emphasize the potential for bioengineered organ replacement in future regenerative therapies. In this review, we will summarize the strategies and the recent progress of research and development for the establishment of organ replacement regenerative therapies.

Original languageEnglish
JournalCornea
Volume32
Issue number11 SUPPL
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

Fingerprint

Tooth
Lacrimal Apparatus
Salivary Glands
Tooth Germ
Cell Engineering
Therapeutics
Bioengineering
Organogenesis
Hair Follicle
Tissue Engineering
Embryonic Stem Cells
Embryonic Development
Cell Biology
Stem Cells
Embryonic Structures
Transplantation
Technology
Wounds and Injuries
Research

Keywords

  • bioengineered organ germ
  • organ germ method
  • organ regeneration
  • organ replacement regenerative therapy
  • stem cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Development and prospects of organ replacement regenerative therapy. / Hirayama, Masatoshi; Oshima, Masamitsu; Tsuji, Takashi.

In: Cornea, Vol. 32, No. 11 SUPPL, 11.2013.

Research output: Contribution to journalArticle

Hirayama, Masatoshi ; Oshima, Masamitsu ; Tsuji, Takashi. / Development and prospects of organ replacement regenerative therapy. In: Cornea. 2013 ; Vol. 32, No. 11 SUPPL.
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