TY - JOUR
T1 - Development and Heterogeneity of Prolactin Cells
AU - Takahashi, Sumio
N1 - Funding Information:
The author expresses cordial thanks to the late professor Yasuo Kobayashi (Faculty of Science, Okayama University) for his continuous hearty encouragement and helpful advice. The author also expresses thanks to Emeritus Professor Howard A. Bern (University of California at Berkeley) for his encouragement in writing the manuscript. The author is grateful to S. Oornizu, T. Osawa, and K. Nakatomi for their energetic help and discussion. This study was supported in part by Grants-in-Aidf or Scientific Research from the Ministry of Education, Science and Culture, Japan, and by the Ryoubiteien Foundation.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Prolactin (PRL) is synthesized in pituitary cells called mammotrophs (PRL cells).Ample evidence demonstrates that the PRL cell population consists of structurally and functionally heterogeneous PRL cells. Multiple variants of PRL molecules are found in various species. Prolactin cells may be divided into various subtypes in the rat and mouse. Secretory activities differ among the PRL cell population. These heterogeneities may reflect various phases of the maturation process of PRL cells, or the integrated outcome of various functional differences in PRL cells. To clarify the significance of heterogeneities among PRL cells, we present updated reports on the differentiation, proliferation, and development of PRL cells, and discuss factors responsible for the functional differences in PRL cell population. The age-related alteration in PRL secretion in the rat is summarized, because it is one of the most important aspects of the developmental changes in PRL cells. A mammosoma-totroph, which secretes growth hormone and PRL, is found in various species. Prolactin cells and somatotrophs are derived from the same lineage. The possible relationship among PRL cells, somatotrophs, and mammosomatotrophs is discussed.
AB - Prolactin (PRL) is synthesized in pituitary cells called mammotrophs (PRL cells).Ample evidence demonstrates that the PRL cell population consists of structurally and functionally heterogeneous PRL cells. Multiple variants of PRL molecules are found in various species. Prolactin cells may be divided into various subtypes in the rat and mouse. Secretory activities differ among the PRL cell population. These heterogeneities may reflect various phases of the maturation process of PRL cells, or the integrated outcome of various functional differences in PRL cells. To clarify the significance of heterogeneities among PRL cells, we present updated reports on the differentiation, proliferation, and development of PRL cells, and discuss factors responsible for the functional differences in PRL cell population. The age-related alteration in PRL secretion in the rat is summarized, because it is one of the most important aspects of the developmental changes in PRL cells. A mammosoma-totroph, which secretes growth hormone and PRL, is found in various species. Prolactin cells and somatotrophs are derived from the same lineage. The possible relationship among PRL cells, somatotrophs, and mammosomatotrophs is discussed.
KW - Key Words:
KW - Mammotroph
KW - Pituitary
KW - Prolactin
KW - Prolactin cell
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U2 - 10.1016/S0074-7696(08)62156-7
DO - 10.1016/S0074-7696(08)62156-7
M3 - Article
C2 - 7706022
AN - SCOPUS:0028959804
VL - 157
SP - 33
EP - 98
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
SN - 1937-6448
IS - C
ER -