Development and evaluation of tetrapod-shaped granular artificial bones

Sungjin Choi, I. Li Liu, Kenichi Yamamoto, Kazuyo Igawa, Manabu Mochizuki, Takamasa Sakai, Ryosuke Echigo, Muneki Honnami, Shigeki Suzuki, Ung Il Chung, Nobuo Sasaki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


We have developed a novel form of granular artificial bone «Tetrabones» with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study we evaluated the physicochemical characteristics of Tetrabones in vitro, and compared their biological and biomechanical properties in vivo to those of conventional β-tricalcium phosphate (β-TCP) granule artificial bone. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of β-TCP granules in vitro. The connectivity of intergranular pores 100, 300, and 400 μm in size were higher in Tetrabones than in the β-TCP granules. Tetrabones showed similar osteoconductivity and biomechanical stiffness to β-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction.

Original languageEnglish
Pages (from-to)2340-2347
Number of pages8
JournalActa Biomaterialia
Issue number6
Publication statusPublished - Jul 2012
Externally publishedYes


  • Bone graft
  • Calcium phosphate
  • Intergranular pores
  • Mechanical properties
  • Tetrapod

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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