Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols

Yumiko Takagi; Takiko Nakatani; Toshiyuki Itoh; Toshiyuki Oshiki

doi:10.1016/S0040-4039(00)01349-6

Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols

Yumiko Takagi, Takiko Nakatani, Toshiyuki Itoh, Toshiyuki Oshiki

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).

Original language	English
Pages (from-to)	7889-7892
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(00)01349-6
Publication status	Published - Oct 7 2000

Keywords

Absolute configuration determination
Fluorinated allylic alcohol
Refined Mosher method
X-ray crystallographic analysis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)01349-6

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abstract = "Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).",

keywords = "Absolute configuration determination, Fluorinated allylic alcohol, Refined Mosher method, X-ray crystallographic analysis",

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AU - Takagi, Yumiko

AU - Nakatani, Takiko

AU - Itoh, Toshiyuki

AU - Oshiki, Toshiyuki

PY - 2000/10/7

Y1 - 2000/10/7

N2 - Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).

AB - Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).

KW - Absolute configuration determination

KW - Fluorinated allylic alcohol

KW - Refined Mosher method

KW - X-ray crystallographic analysis

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VL - 41

SP - 7889

EP - 7892

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 41

ER -

Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols

Abstract

Keywords

ASJC Scopus subject areas

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