Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols

Yumiko Takagi, Takiko Nakatani, Toshiyuki Itoh, Toshiyuki Oshiki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).

Original languageEnglish
Pages (from-to)7889-7892
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number41
DOIs
Publication statusPublished - Oct 7 2000

Keywords

  • Absolute configuration determination
  • Fluorinated allylic alcohol
  • Refined Mosher method
  • X-ray crystallographic analysis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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