Abstract
Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method). (C) 2000 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 7889-7892 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 41 |
| Publication status | Published - Oct 7 2000 |
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Keywords
- Absolute configuration determination
- Fluorinated allylic alcohol
- Refined Mosher method
- X-ray crystallographic analysis
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols. / Takagi, Y.; Nakatani, T.; Itoh, T.; Oshiki, Toshiyuki.
In: Tetrahedron Letters, Vol. 41, No. 41, 07.10.2000, p. 7889-7892.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols
AU - Takagi, Y.
AU - Nakatani, T.
AU - Itoh, T.
AU - Oshiki, Toshiyuki
PY - 2000/10/7
Y1 - 2000/10/7
N2 - Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method). (C) 2000 Elsevier Science Ltd.
AB - Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method). (C) 2000 Elsevier Science Ltd.
KW - Absolute configuration determination
KW - Fluorinated allylic alcohol
KW - Refined Mosher method
KW - X-ray crystallographic analysis
UR - http://www.scopus.com/inward/record.url?scp=0034619123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034619123&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034619123
VL - 41
SP - 7889
EP - 7892
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 41
ER -