Abstract
Optically active 1,1,2-trifluoro- or 1,2-difluoroallylic alcohols were prepared via a lipase-catalyzed reaction and their absolute configuration was determined by an X-ray crystallographic analysis of the corresponding ferrocene ester along with the refined Mosher method (the Kusumi-Ohtani method).
| Original language | English |
|---|---|
| Pages (from-to) | 7889-7892 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 41 |
| DOIs | |
| Publication status | Published - Oct 7 2000 |
Keywords
- Absolute configuration determination
- Fluorinated allylic alcohol
- Refined Mosher method
- X-ray crystallographic analysis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Takagi, Y., Nakatani, T., Itoh, T., & Oshiki, T. (2000). Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcohols. Tetrahedron Letters, 41(41), 7889-7892. https://doi.org/10.1016/S0040-4039(00)01349-6