Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy

Yuji Hiramatsu, Ikki Shimizu, Yasue Omori, Masao Nakabayashi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Glycemic control is an important issue in gestational diabetes mellitus (GDM) and in diabetic pregnant women. We determined the reference intervals of glycated albumin (GA) and hemoglobin A1c(HbA1c) as glycemic control markers in healthy Japanese pregnant women and analyzed their time courses and factors that influence these variables during pregnancy. 676 women were screened for the present study. After the exclusion of non-pregnant and puerperal women, 574 women were studied to determine the reference intervals. HbA1c, GA, casual plasma glucose, urinary glucose, urinary protein, and body mass index (BMI) (non-pregnancy) were measured. HbA1c levels significantly decreased in the second trimester of pregnancy and increased in the third trimester, while GA levels significantly decreased towards the third trimester. Casual plasma glucose levels decreased in the first trimester and subsequently remained constant. The reference intervals of GA and HbA1c in the healthy pregnant women were 11.5-15.7% and 4.5-5.7%, respectively. GA levels were lower (p2), and HbA1c levels were higher (p

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalEndocrine Journal
Volume59
Issue number2
DOIs
Publication statusPublished - 2012

Fingerprint

Glycosylated Hemoglobin A
Pregnant Women
Pregnancy
Hemoglobins
Third Pregnancy Trimester
Glucose
Gestational Diabetes
Second Pregnancy Trimester
First Pregnancy Trimester
Body Mass Index
glycosylated serum albumin
Proteins

Keywords

  • Diabetes mellitus
  • Glycated albumin (GA)
  • Glycated hemoglobin (HbA1c)
  • Healthy pregnant women
  • Reference intervals

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Determination of reference intervals of glycated albumin and hemoglobin A1c in healthy pregnant Japanese women and analysis of their time courses and influencing factors during pregnancy. / Hiramatsu, Yuji; Shimizu, Ikki; Omori, Yasue; Nakabayashi, Masao.

In: Endocrine Journal, Vol. 59, No. 2, 2012, p. 145-151.

Research output: Contribution to journalArticle

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