TY - JOUR
T1 - Determination of formaldehyde in urine by headspace gas chromatography
AU - Takeuchi, Akito
AU - Takigawa, Tomoko
AU - Abe, Mikiko
AU - Kawai, Toshio
AU - Endo, Yoko
AU - Yasugi, Tomojiro
AU - Endo, Ginji
AU - Ogino, Keiki
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 μg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 μg/L. This method can be used successfully to measure formaldehyde in urine.
AB - Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 μg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 μg/L. This method can be used successfully to measure formaldehyde in urine.
KW - Formaldehyde
KW - Gas chromatography
KW - Headspace analysis
KW - Human urine
KW - O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine
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U2 - 10.1007/s00128-007-9172-0
DO - 10.1007/s00128-007-9172-0
M3 - Article
C2 - 17618393
AN - SCOPUS:34548119485
VL - 79
SP - 1
EP - 4
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
SN - 0007-4861
IS - 1
ER -