Abstract
Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 μg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 μg/L. This method can be used successfully to measure formaldehyde in urine.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Bulletin of Environmental Contamination and Toxicology |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2007 |
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Keywords
- Formaldehyde
- Gas chromatography
- Headspace analysis
- Human urine
- O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine
ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Toxicology
Cite this
Determination of formaldehyde in urine by headspace gas chromatography. / Takeuchi, Akito; Takigawa, Tomoko; Abe, Mikiko; Kawai, Toshio; Endo, Yoko; Yasugi, Tomojiro; Endo, Ginji; Ogino, Keiki.
In: Bulletin of Environmental Contamination and Toxicology, Vol. 79, No. 1, 07.2007, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of formaldehyde in urine by headspace gas chromatography
AU - Takeuchi, Akito
AU - Takigawa, Tomoko
AU - Abe, Mikiko
AU - Kawai, Toshio
AU - Endo, Yoko
AU - Yasugi, Tomojiro
AU - Endo, Ginji
AU - Ogino, Keiki
PY - 2007/7
Y1 - 2007/7
N2 - Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 μg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 μg/L. This method can be used successfully to measure formaldehyde in urine.
AB - Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 μg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 μg/L. This method can be used successfully to measure formaldehyde in urine.
KW - Formaldehyde
KW - Gas chromatography
KW - Headspace analysis
KW - Human urine
KW - O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine
UR - http://www.scopus.com/inward/record.url?scp=34548119485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548119485&partnerID=8YFLogxK
U2 - 10.1007/s00128-007-9172-0
DO - 10.1007/s00128-007-9172-0
M3 - Article
C2 - 17618393
AN - SCOPUS:34548119485
VL - 79
SP - 1
EP - 4
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
SN - 0007-4861
IS - 1
ER -