Determination of absolute configuration of C14-C23 fragment in symbiodinolide

Chunguang Han, Yoshi Yamano, Masaki Kita, Hiroyoshi Takamura, Daisuke Uemura

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The degradation product C14-C23 2 was obtained using ethenolysis with the 2nd-generation Hoveyda-Grubbs catalyst from 62-membered lactone in symbiodinolide (1). The absolute configurations of three chiral centers in fragment 2 were assigned as 17R, 18R, and 21R by a combination of J-based configuration analysis and the Mosher-Riguera method.

Original languageEnglish
Pages (from-to)5280-5282
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number37
DOIs
Publication statusPublished - Sep 16 2009
Externally publishedYes

Keywords

  • 2nd-generation Hoveyda-Grubbs catalyst
  • Absolute configuration
  • Ethenolysis
  • J-based configuration analysis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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