TY - JOUR
T1 - Detection of NO-induced DNA lesions by the modified aldehyde reactive probe (ARP) assay.
AU - Nakano, Toshiaki
AU - Terato, Hiroaki
AU - Yoshioka, Yoshihiro
AU - Ohyama, Yoshihiko
AU - Kubo, Kihei
AU - Ide, Hiroshi
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2002
Y1 - 2002
N2 - When DNA is exposed to NO or HNO2, oxanine (Oxa) is formed as a major guanine lesion. For highly sensitive detection of Oxa using ARP, a probe molecule for DNA damage detection, the reactivity of ARP to Oxa was examined. Oxa site-specifically embedded in an oligonucleotide reacted with ARP but it took relatively long time (ca. 24 h) to completely convert Oxa to an ARP-labeled form.
AB - When DNA is exposed to NO or HNO2, oxanine (Oxa) is formed as a major guanine lesion. For highly sensitive detection of Oxa using ARP, a probe molecule for DNA damage detection, the reactivity of ARP to Oxa was examined. Oxa site-specifically embedded in an oligonucleotide reacted with ARP but it took relatively long time (ca. 24 h) to completely convert Oxa to an ARP-labeled form.
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U2 - 10.1093/nass/2.1.239
DO - 10.1093/nass/2.1.239
M3 - Article
C2 - 12903194
AN - SCOPUS:0042819884
SP - 239
EP - 240
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 2
ER -