Detection of Minimal Residual Disease in Childhood Leukemia with the Polymerase Chain Reaction

A. Beishuizen, K. Hählen, E. R. Van Wering, J. J.M. Van Dongen, Isaak Hakim, Ninette Amariglio, Frida Brok-Simoni, Gideon Rechavi, Bracha Ramot, Giovanni Rovera, Robert Wasserman, Masao Yamada

Research output: Contribution to journalLetterpeer-review

28 Citations (Scopus)

Abstract

To the Editor: Rearrangement of the variable (diversity) and joining gene segments of the immunoglobulin and T-cell–receptor genes generates unique DNA sequences at the junctional region of these gene segments. This junctional region is different in each lymphocyte. In the case of immunoglobulin genes, it is known as the complementarity-determining region III (CDRIII).1 Since a neoplasm represents a clonal expansion of a single malignantly transformed cell, junctional regions of rearranged immunoglobulin and T-cell–receptor genes in leukemias can be regarded as “tumor-specific” markers.2 3 4 Yamada et al. (Aug. 16 issue)5 used the polymerase chain reaction—mediated amplification of “tumor-specific” immunoglobulin heavy-chain gene junctional.

Original languageEnglish
Pages (from-to)772-775
Number of pages4
JournalNew England Journal of Medicine
Volume324
Issue number11
DOIs
Publication statusPublished - Mar 14 1991

ASJC Scopus subject areas

  • Medicine(all)

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