Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

Keita Kobayashi, Kenji Yokota, Tadashi Yoshino, Yoshiro Kawahara, Ashoka Dey, Yoshikazu Hirai, Keiji Oguma, Tadaatsu Akagi

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Abstract

Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

Original languageEnglish
Pages (from-to)396-398
Number of pages3
JournalJournal of Clinical Pathology
Volume51
Issue number5
Publication statusPublished - 1998

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Follicular Dendritic Cells
Chaperonin 60
Marginal Zone B-Cell Lymphoma
Germinal Center
B-Cell Lymphoma
Gastric Mucosa
Helicobacter pylori
Non-Hodgkin's Lymphoma
Pylorus
Antigens
Stomach
Monoclonal Antibodies
Antibodies
Heat-Shock Proteins
Anti-Idiotypic Antibodies
Lymph Nodes
Epithelial Cells
Rabbits

Keywords

  • Helicobacter pylori
  • Immunohistochemistry
  • MALT lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)",
abstract = "Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.",
keywords = "Helicobacter pylori, Immunohistochemistry, MALT lymphoma",
author = "Keita Kobayashi and Kenji Yokota and Tadashi Yoshino and Yoshiro Kawahara and Ashoka Dey and Yoshikazu Hirai and Keiji Oguma and Tadaatsu Akagi",
year = "1998",
language = "English",
volume = "51",
pages = "396--398",
journal = "Journal of Clinical Pathology - Clinical Molecular Pathology",
issn = "0021-9746",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

AU - Kobayashi, Keita

AU - Yokota, Kenji

AU - Yoshino, Tadashi

AU - Kawahara, Yoshiro

AU - Dey, Ashoka

AU - Hirai, Yoshikazu

AU - Oguma, Keiji

AU - Akagi, Tadaatsu

PY - 1998

Y1 - 1998

N2 - Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

AB - Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

KW - Helicobacter pylori

KW - Immunohistochemistry

KW - MALT lymphoma

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