Detection of fecal DNA methylation for colorectal neoplasia: Does it lead to an optimal screening test?

Takeshi Nagasaka, Ajay Goel, Nagahide Matsubara, Noriaki Tanaka

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component in the evolution of human cancers. With our limited knowledge of the molecular basis and timing of the initiation of altered methylation events in the stepwise progression of cancers, the biggest challenge we currently face is to identify novel biomarkers and technologies for the timely screening of patients carrying such alterations. One such strategy would be to develop tests for the detection of fecal DNA methylation patterns that will improve the sensitivity of noninvasive screening tests for colorectal neoplasia, and moreover, will decrease both mortality and the incremental costs of treating colorectal cancers. Copyright

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalActa medica Okayama
Volume60
Issue number5
Publication statusPublished - Oct 2006

Keywords

  • Colorectal cancer
  • Epigenetics
  • Fecal DNA
  • Methylation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Detection of fecal DNA methylation for colorectal neoplasia: Does it lead to an optimal screening test?'. Together they form a unique fingerprint.

  • Cite this