Abstract
The desymmetrization of meso-glycerol derivatives bearing a 3-pyrroline-1-carbonyl (Pyroc) directing group is demonstrated through an enantioselective acylation reaction promoted by L-histidine-derived bifunctional catalysts. The desired monoacylated products are obtained in good yields (up to 74%) with high enantioselectivities (up to 99% ee).
| Original language | English |
|---|---|
| Pages (from-to) | 1938-1942 |
| Number of pages | 5 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 353 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Aug 2011 |
| Externally published | Yes |
Keywords
- L -histidine
- Pyroc (3-pyrroline-1-carbonyl) group
- asymmetric acylation
- desymmetrization
- glycerol
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry