The desymmetrization of meso-glycerol derivatives bearing a 3-pyrroline-1-carbonyl (Pyroc) directing group is demonstrated through an enantioselective acylation reaction promoted by L-histidine-derived bifunctional catalysts. The desired monoacylated products are obtained in good yields (up to 74%) with high enantioselectivities (up to 99% ee).
- L -histidine
- Pyroc (3-pyrroline-1-carbonyl) group
- asymmetric acylation
ASJC Scopus subject areas
- Organic Chemistry