Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators

Novel human PPARα-selective activators

Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Yukie Takahashi, Tomohiro Ide, Masaki Tsunoda, Koji Murakami, Katsuya Awano

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 7 2002
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
Derivatives
Acids
Structure-Activity Relationship
Transcriptional Activation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators : Novel human PPARα-selective activators. / Miyachi, Hiroyuki; Nomura, Masahiro; Tanase, Takahiro; Takahashi, Yukie; Ide, Tomohiro; Tsunoda, Masaki; Murakami, Koji; Awano, Katsuya.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 1, 07.01.2002, p. 77-80.

Research output: Contribution to journalArticle

Miyachi, Hiroyuki ; Nomura, Masahiro ; Tanase, Takahiro ; Takahashi, Yukie ; Ide, Tomohiro ; Tsunoda, Masaki ; Murakami, Koji ; Awano, Katsuya. / Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators : Novel human PPARα-selective activators. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 1. pp. 77-80.
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