Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: Novel human PPARα-selective activators

Hiroyuki Miyachi, Masahiro Nomura, Takahiro Tanase, Yukie Takahashi, Tomohiro Ide, Masaki Tsunoda, Koji Murakami, Katsuya Awano

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43 Citations (Scopus)

Abstract

A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 7 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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