Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kenichi Kobayashi, Yusuke Fujii, Yuichiro Hirayama, Shinichi Kobayashi, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.

Original languageEnglish
Pages (from-to)1290-1293
Number of pages4
JournalOrganic Letters
Volume14
Issue number5
DOIs
Publication statusPublished - Mar 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Kobayashi, K., Fujii, Y., Hirayama, Y., Kobayashi, S., Hayakawa, I., & Kigoshi, H. (2012). Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound. Organic Letters, 14(5), 1290-1293. https://doi.org/10.1021/ol300182r