Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kenichi Kobayashi, Yusuke Fujii, Yuichiro Hirayama, Shinichi Kobayashi, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.

Original languageEnglish
Pages (from-to)1290-1293
Number of pages4
JournalOrganic Letters
Volume14
Issue number5
DOIs
Publication statusPublished - Mar 2 2012
Externally publishedYes

Fingerprint

Cytotoxicity
evaluation
Actins
synthesis
activity (biology)
Bioactivity
mycalolide B
aplyronine A

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound. / Kobayashi, Kenichi; Fujii, Yusuke; Hirayama, Yuichiro; Kobayashi, Shinichi; Hayakawa, Ichiro; Kigoshi, Hideo.

In: Organic Letters, Vol. 14, No. 5, 02.03.2012, p. 1290-1293.

Research output: Contribution to journalArticle

Kobayashi, K, Fujii, Y, Hirayama, Y, Kobayashi, S, Hayakawa, I & Kigoshi, H 2012, 'Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound', Organic Letters, vol. 14, no. 5, pp. 1290-1293. https://doi.org/10.1021/ol300182r
Kobayashi, Kenichi ; Fujii, Yusuke ; Hirayama, Yuichiro ; Kobayashi, Shinichi ; Hayakawa, Ichiro ; Kigoshi, Hideo. / Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound. In: Organic Letters. 2012 ; Vol. 14, No. 5. pp. 1290-1293.
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