@article{d7f1f2693fc442cb97a88107ee9d79ec,
title = "Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone",
abstract = "Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O 7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.",
keywords = "Antitumor activity, Glaziovianin A, Isoflavone, Molecular probes, Structure-activity relationship study",
author = "Ichiro Hayakawa and Akiyuki Ikedo and Takumi Chinen and Takeo Usui and Hideo Kigoshi",
note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research on Innovative Areas {\textquoteleft}Chemical Biology of Natural Products{\textquoteright} and for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) / Japanese Society for the Promotion of Science (JSPS) ; by a grant from the Uehara Memorial Foundation ; and by a grant from the University of Tsukuba, Strategic Initiatives (A), Center for Creation of Functional Materials (CCFM) . I.H. thanks The Society of Synthetic Organic Chemistry, Japan (Meiji Seika Award in Synthetic Organic Chemistry, Japan) and the Suntory Institute for Bioorganic Research (SUNBOR GRANT) for their financial support. ",
year = "2012",
month = oct,
day = "1",
doi = "10.1016/j.bmc.2012.08.005",
language = "English",
volume = "20",
pages = "5745--5756",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "19",
}