Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Hiroyuki Miyachi; Hiromi Kiyota; Mitsuru Segawa

doi:10.1016/S0960-894X(99)00517-X

Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M₂ and M₃ muscarinic receptors, the structure-activity relationships of these compounds are discussed.

Original language	English
Pages (from-to)	3003-3008
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(99)00517-X
Publication status	Published - Oct 18 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(99)00517-X

Fingerprint Dive into the research topics of 'Design, synthesis and antimuscarinic activity of some imidazolium derivatives'. Together they form a unique fingerprint.

Cite this

@article{d66c066274ee42c2a5406b886083b6d9,

title = "Design, synthesis and antimuscarinic activity of some imidazolium derivatives",

abstract = "A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.",

author = "Hiroyuki Miyachi and Hiromi Kiyota and Mitsuru Segawa",

year = "1999",

month = oct,

day = "18",

doi = "10.1016/S0960-894X(99)00517-X",

language = "English",

volume = "9",

pages = "3003--3008",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "20",

}

TY - JOUR

T1 - Design, synthesis and antimuscarinic activity of some imidazolium derivatives

AU - Miyachi, Hiroyuki

AU - Kiyota, Hiromi

AU - Segawa, Mitsuru

PY - 1999/10/18

Y1 - 1999/10/18

N2 - A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.

AB - A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0033581633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033581633&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(99)00517-X

DO - 10.1016/S0960-894X(99)00517-X

M3 - Article

C2 - 10571164

AN - SCOPUS:0033581633

VL - 9

SP - 3003

EP - 3008

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 20

ER -

Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this