Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.

Original languageEnglish
Pages (from-to)3003-3008
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number20
DOIs
Publication statusPublished - Oct 18 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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