Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Hiroyuki Miyachi; Hiromi Kiyota; Mitsuru Segawa

doi:10.1016/S0960-894X(99)00517-X

Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M₂ and M₃ muscarinic receptors, the structure-activity relationships of these compounds are discussed.

Original language	English
Pages (from-to)	3003-3008
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(99)00517-X
Publication status	Published - Oct 18 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00517-X

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abstract = "A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.",

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AB - A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.

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Design, synthesis and antimuscarinic activity of some imidazolium derivatives

Abstract

ASJC Scopus subject areas

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