Abstract
Poly(D,L-lactide) (PDLLA) microspheres with narrow diameter distribution were prepared by dispersion polymerization of D,L-lactide in xylene/ heptane (1:2, v/v) using poly(dodecyl methacrylate)-g-poly(D,L-lactide) (PDMA-g-PDLLA) as a dispersion stabilizer. The particle diameters of PDLLA microspheres were controlled from 200 nm to 5 μm by altering the concentration and the graft chain number of PDMA-g-PDLLA. The effect of the copolymer composition on the particle diameter was investigated to clarify an important factor of the copolymer structure for the control of the particle diameter. As a result, it was necessary for anchor block in diblock copolymer as a dispersion stabilizer to have low solubility in the solution rather than the compatibility with particles. Moreover, we confirmed by dynamic light scattering measurement that PDMA-g-PDLLA formed micelles in the solution. In conclusion, it was clarified that PDLLA microspheres with a wide range of particle diameter were prepared due to the different kinetic stability of micelles.
| Original language | English |
|---|---|
| Pages (from-to) | 525-532 |
| Number of pages | 8 |
| Journal | Colloid and Polymer Science |
| Volume | 287 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Copolymeric micelles
- Dispersion polymerization
- Graft copolymeric stabilizer
- Microsphere
- Poly(D, L-lactide)
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Materials Chemistry
- Colloid and Surface Chemistry
Cite this
Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide. / Muranaka, Makoto; Yoshizawa, Hidekazu; Ono, Tsutomu.
In: Colloid and Polymer Science, Vol. 287, No. 5, 2009, p. 525-532.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide
AU - Muranaka, Makoto
AU - Yoshizawa, Hidekazu
AU - Ono, Tsutomu
PY - 2009
Y1 - 2009
N2 - Poly(D,L-lactide) (PDLLA) microspheres with narrow diameter distribution were prepared by dispersion polymerization of D,L-lactide in xylene/ heptane (1:2, v/v) using poly(dodecyl methacrylate)-g-poly(D,L-lactide) (PDMA-g-PDLLA) as a dispersion stabilizer. The particle diameters of PDLLA microspheres were controlled from 200 nm to 5 μm by altering the concentration and the graft chain number of PDMA-g-PDLLA. The effect of the copolymer composition on the particle diameter was investigated to clarify an important factor of the copolymer structure for the control of the particle diameter. As a result, it was necessary for anchor block in diblock copolymer as a dispersion stabilizer to have low solubility in the solution rather than the compatibility with particles. Moreover, we confirmed by dynamic light scattering measurement that PDMA-g-PDLLA formed micelles in the solution. In conclusion, it was clarified that PDLLA microspheres with a wide range of particle diameter were prepared due to the different kinetic stability of micelles.
AB - Poly(D,L-lactide) (PDLLA) microspheres with narrow diameter distribution were prepared by dispersion polymerization of D,L-lactide in xylene/ heptane (1:2, v/v) using poly(dodecyl methacrylate)-g-poly(D,L-lactide) (PDMA-g-PDLLA) as a dispersion stabilizer. The particle diameters of PDLLA microspheres were controlled from 200 nm to 5 μm by altering the concentration and the graft chain number of PDMA-g-PDLLA. The effect of the copolymer composition on the particle diameter was investigated to clarify an important factor of the copolymer structure for the control of the particle diameter. As a result, it was necessary for anchor block in diblock copolymer as a dispersion stabilizer to have low solubility in the solution rather than the compatibility with particles. Moreover, we confirmed by dynamic light scattering measurement that PDMA-g-PDLLA formed micelles in the solution. In conclusion, it was clarified that PDLLA microspheres with a wide range of particle diameter were prepared due to the different kinetic stability of micelles.
KW - Copolymeric micelles
KW - Dispersion polymerization
KW - Graft copolymeric stabilizer
KW - Microsphere
KW - Poly(D, L-lactide)
UR - http://www.scopus.com/inward/record.url?scp=67349212907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349212907&partnerID=8YFLogxK
U2 - 10.1007/s00396-009-1998-z
DO - 10.1007/s00396-009-1998-z
M3 - Article
AN - SCOPUS:67349212907
VL - 287
SP - 525
EP - 532
JO - Colloid and Polymer Science
JF - Colloid and Polymer Science
SN - 0303-402X
IS - 5
ER -