Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

Shinichiro Kamino, Hayato Ichikawa, Shun ichi Wada, Yuka Horio, Yoshihide Usami, Takako Yamaguchi, Toshiki Koda, Aki Harada, Kazusa Shimanuki, Masao Arimoto, Mitsunobu Doi, Yoshikazu Fujita

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy.

Original languageEnglish
Pages (from-to)4380-4384
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number15
DOIs
Publication statusPublished - Aug 1 2008
Externally publishedYes

Fingerprint

Xanthenes
Staining and Labeling
Derivatives
Confocal Microscopy
Microscopic examination
Physical properties
Fluorescence
Scanning
Imaging techniques
Lasers

Keywords

  • Chemical biology
  • Photochemical properties
  • Regioisomerically pure
  • Unsymmetrical xanthene derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties. / Kamino, Shinichiro; Ichikawa, Hayato; Wada, Shun ichi; Horio, Yuka; Usami, Yoshihide; Yamaguchi, Takako; Koda, Toshiki; Harada, Aki; Shimanuki, Kazusa; Arimoto, Masao; Doi, Mitsunobu; Fujita, Yoshikazu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 15, 01.08.2008, p. 4380-4384.

Research output: Contribution to journalArticle

Kamino, S, Ichikawa, H, Wada, SI, Horio, Y, Usami, Y, Yamaguchi, T, Koda, T, Harada, A, Shimanuki, K, Arimoto, M, Doi, M & Fujita, Y 2008, 'Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 15, pp. 4380-4384. https://doi.org/10.1016/j.bmcl.2008.06.065
Kamino, Shinichiro ; Ichikawa, Hayato ; Wada, Shun ichi ; Horio, Yuka ; Usami, Yoshihide ; Yamaguchi, Takako ; Koda, Toshiki ; Harada, Aki ; Shimanuki, Kazusa ; Arimoto, Masao ; Doi, Mitsunobu ; Fujita, Yoshikazu. / Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 15. pp. 4380-4384.
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AU - Usami, Yoshihide

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