Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

Shinichiro Kamino, Hayato Ichikawa, Shun ichi Wada, Yuka Horio, Yoshihide Usami, Takako Yamaguchi, Toshiki Koda, Aki Harada, Kazusa Shimanuki, Masao Arimoto, Mitsunobu Doi, Yoshikazu Fujita

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy.

Original languageEnglish
Pages (from-to)4380-4384
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number15
DOIs
Publication statusPublished - Aug 1 2008

Keywords

  • Chemical biology
  • Photochemical properties
  • Regioisomerically pure
  • Unsymmetrical xanthene derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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