Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists

Kenji Kishida, Atsushi Aoyama, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

Original languageEnglish
Pages (from-to)1524-1528
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Liver
Structure-Activity Relationship
Ligands
phthalimide
Liver X Receptors

Keywords

  • Fluorescent ligand
  • Liver X receptor
  • Liver X receptor antagonist

ASJC Scopus subject areas

  • Drug Discovery
  • Chemistry(all)
  • Medicine(all)

Cite this

Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists. / Kishida, Kenji; Aoyama, Atsushi; Hashimoto, Yuichi; Miyachi, Hiroyuki.

In: Chemical and Pharmaceutical Bulletin, Vol. 58, No. 11, 11.2010, p. 1524-1528.

Research output: Contribution to journalArticle

Kishida, Kenji ; Aoyama, Atsushi ; Hashimoto, Yuichi ; Miyachi, Hiroyuki. / Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists. In: Chemical and Pharmaceutical Bulletin. 2010 ; Vol. 58, No. 11. pp. 1524-1528.
@article{acd2071d320a423e93ca95aba63f367f,
title = "Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists",
abstract = "Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.",
keywords = "Fluorescent ligand, Liver X receptor, Liver X receptor antagonist",
author = "Kenji Kishida and Atsushi Aoyama and Yuichi Hashimoto and Hiroyuki Miyachi",
year = "2010",
month = "11",
doi = "10.1248/cpb.58.1525",
language = "English",
volume = "58",
pages = "1524--1528",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "11",

}

TY - JOUR

T1 - Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists

AU - Kishida, Kenji

AU - Aoyama, Atsushi

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

PY - 2010/11

Y1 - 2010/11

N2 - Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

AB - Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

KW - Fluorescent ligand

KW - Liver X receptor

KW - Liver X receptor antagonist

UR - http://www.scopus.com/inward/record.url?scp=78049459888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049459888&partnerID=8YFLogxK

U2 - 10.1248/cpb.58.1525

DO - 10.1248/cpb.58.1525

M3 - Article

C2 - 21048348

AN - SCOPUS:78049459888

VL - 58

SP - 1524

EP - 1528

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 11

ER -