Abstract
The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 5745-5749 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 21 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2011 |
| Externally published | Yes |
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Keywords
- Annonaceous acetogenin
- Antitumor agent
- Chemical synthesis
- Fluorinated analogue
- Structure-activity relationship
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines. / Kojima, Naoto; Suga, Yuki; Hayashi, Hiromi; Yamori, Takao; Yoshimitsu, Takehiko; Tanaka, Tetsuaki.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 19, 01.10.2011, p. 5745-5749.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines
AU - Kojima, Naoto
AU - Suga, Yuki
AU - Hayashi, Hiromi
AU - Yamori, Takao
AU - Yoshimitsu, Takehiko
AU - Tanaka, Tetsuaki
PY - 2011/10/1
Y1 - 2011/10/1
N2 - The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
AB - The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
KW - Annonaceous acetogenin
KW - Antitumor agent
KW - Chemical synthesis
KW - Fluorinated analogue
KW - Structure-activity relationship
UR - http://www.scopus.com/inward/record.url?scp=80052577176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052577176&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2011.08.011
DO - 10.1016/j.bmcl.2011.08.011
M3 - Article
C2 - 21875800
AN - SCOPUS:80052577176
VL - 21
SP - 5745
EP - 5749
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -