Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

Naoto Kojima; Yuki Suga; Hiromi Hayashi; Takao Yamori; Takehiko Yoshimitsu; Tetsuaki Tanaka

doi:10.1016/j.bmcl.2011.08.011

Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

Naoto Kojima, Yuki Suga, Hiromi Hayashi, Takao Yamori, Takehiko Yoshimitsu, Tetsuaki Tanaka

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.

Original language	English
Pages (from-to)	5745-5749
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2011.08.011
Publication status	Published - Oct 1 2011
Externally published	Yes

Keywords

Annonaceous acetogenin
Antitumor agent
Chemical synthesis
Fluorinated analogue
Structure-activity relationship

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.08.011

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Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines. / Kojima, Naoto; Suga, Yuki; Hayashi, Hiromi; Yamori, Takao; Yoshimitsu, Takehiko; Tanaka, Tetsuaki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 19, 01.10.2011, p. 5745-5749.

Research output: Contribution to journal › Article › peer-review

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