Abstract
The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 5745-5749 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 21 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2011 |
| Externally published | Yes |
Keywords
- Annonaceous acetogenin
- Antitumor agent
- Chemical synthesis
- Fluorinated analogue
- Structure-activity relationship
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Kojima, N., Suga, Y., Hayashi, H., Yamori, T., Yoshimitsu, T., & Tanaka, T. (2011). Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines. Bioorganic and Medicinal Chemistry Letters, 21(19), 5745-5749. https://doi.org/10.1016/j.bmcl.2011.08.011