TY - JOUR
T1 - Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines
AU - Kojima, Naoto
AU - Suga, Yuki
AU - Hayashi, Hiromi
AU - Yamori, Takao
AU - Yoshimitsu, Takehiko
AU - Tanaka, Tetsuaki
N1 - Funding Information:
In vitro antiproliferative activities of C35-fluorinated solamins against human cancer cell lines were examined by the Screening Committee of New Anticancer Agents supported by a Grant-in-Aid for Scientific Research on Priority Area ‘Cancer’ from The Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT). This work was supported by a Grant-in-Aid for Young Scientists (B) [No. 21790113, 23790130], a Grant-in-Aid for Scientific Research (B) [No. 22390021], and a Grant-in-Aid for Scientific Research on Innovative Areas [No. 22136006] from The Ministry of Education, Culture, Sports, Science and Technology, Japan .
PY - 2011/10/1
Y1 - 2011/10/1
N2 - The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
AB - The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
KW - Annonaceous acetogenin
KW - Antitumor agent
KW - Chemical synthesis
KW - Fluorinated analogue
KW - Structure-activity relationship
UR - http://www.scopus.com/inward/record.url?scp=80052577176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052577176&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2011.08.011
DO - 10.1016/j.bmcl.2011.08.011
M3 - Article
C2 - 21875800
AN - SCOPUS:80052577176
VL - 21
SP - 5745
EP - 5749
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -
