@article{a703180d2b1141aa8359bde328c40cd1,
title = "Design and de Novo Synthesis of 6-Aza-artemisinins",
abstract = "Development of designer natural product variants, 6-aza-artemisinins, enabled us to achieve structural modification of the hitherto unexplored cyclohexane moiety of artemisinin and concise de novo synthesis of the tetracyclic scaffold in just four steps from the modular assembly of three simple building blocks. This expeditious catalytic asymmetric synthetic approach generated lead candidates exhibiting superior in vivo antimalarial activities to artemisinin.",
author = "Bonepally, {Karunakar Reddy} and Takahisa Hiruma and Haruki Mizoguchi and Kyohei Ochiai and Shun Suzuki and Hideaki Oikawa and Aki Ishiyama and Rei Hokari and Masato Iwatsuki and Kazuhiko Otoguro and Satoshi Omura and Hiroki Oguri",
note = "Funding Information: The authors thank Drs. Timothy N. C. Wells, Jeremy Burrows, and Didier Leroy of Medicines for Malaria Venture (MMV) for their invaluable advice and continuous support. The authors thank Mr. Takashi Matsumoto (Rigaku) and Mr. Ryo Watanabe (Hokkaido Univ.) for X-ray analysis. This work was supported in part by the GHIT fund HTLP RFP (2014-001), JSPS KAKENHI Grant Numbers JP23310156, JP26102702, and JP16H01135, the Naito Foundation, and the Uehara Memorial Foundation. This work was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, “Asian Chemical Biology Initiative”, and JSPS A3 Foresight Program.",
year = "2018",
month = aug,
day = "3",
doi = "10.1021/acs.orglett.8b01987",
language = "English",
volume = "20",
pages = "4667--4671",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "15",
}