Abstract
Background and Aim: Hepatocellular carcinoma (HCC) is a hypervascular tumor, and angiogenesis plays an important role in its development. Previously, we demonstrated that des-γ-carboxyl prothrombin (DCP) promotes both cell proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inducing the autophosphorylation of kinase insert domain receptor (KDR). In the present study, DCP-associated tumor angiogenesis was assessed by comparing hypovascular and common hypervascular HCC. Methods: The solitary HCCs of 827 patients were classified into two groups according to the tumor density at the arterial phase of a dynamic computed tomography scan; the initial clinical data of patients with the hyper- and hypovascular types were compared. The HCC tissues from 95 tumors were analyzed by immunohistochemical staining for DCP and phosphorylated KDR, and intratumoral microvessel density (MVD) was analyzed to evaluate microvessel angiogenesis. Results: The serum DCP levels (320±3532mAU/mL) and tumor size (18.4±9.0mm) of patients with hypervascular HCC were significantly greater than those with hypovascular HCC (38.7±80mAU/mL and 14.6±5.2mm, P
| Original language | English |
|---|---|
| Pages (from-to) | 1602-1608 |
| Number of pages | 7 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 27 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Des-γ-carboxyl prothrombin
- Hepatocellular carcinoma
- Intratumoral microvessel density
- Kinase insert domain receptor
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma. / Matsubara, Minoru; Shiraha, Hidenori; Kataoka, Jyunro; Iwamuro, Masaya; Horiguchi, Shigeru; Nishina, Shin Ichi; Takaoka, Nobuyuki; Uemura, Masayuki; Takaki, Akinobu; Nakamura, Shinichiro; Kobayashi, Yoshiyuki; Nouso, Kazuhiro; Yamamoto, Kazuhide.
In: Journal of Gastroenterology and Hepatology (Australia), Vol. 27, No. 10, 2012, p. 1602-1608.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma
AU - Matsubara, Minoru
AU - Shiraha, Hidenori
AU - Kataoka, Jyunro
AU - Iwamuro, Masaya
AU - Horiguchi, Shigeru
AU - Nishina, Shin Ichi
AU - Takaoka, Nobuyuki
AU - Uemura, Masayuki
AU - Takaki, Akinobu
AU - Nakamura, Shinichiro
AU - Kobayashi, Yoshiyuki
AU - Nouso, Kazuhiro
AU - Yamamoto, Kazuhide
PY - 2012
Y1 - 2012
N2 - Background and Aim: Hepatocellular carcinoma (HCC) is a hypervascular tumor, and angiogenesis plays an important role in its development. Previously, we demonstrated that des-γ-carboxyl prothrombin (DCP) promotes both cell proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inducing the autophosphorylation of kinase insert domain receptor (KDR). In the present study, DCP-associated tumor angiogenesis was assessed by comparing hypovascular and common hypervascular HCC. Methods: The solitary HCCs of 827 patients were classified into two groups according to the tumor density at the arterial phase of a dynamic computed tomography scan; the initial clinical data of patients with the hyper- and hypovascular types were compared. The HCC tissues from 95 tumors were analyzed by immunohistochemical staining for DCP and phosphorylated KDR, and intratumoral microvessel density (MVD) was analyzed to evaluate microvessel angiogenesis. Results: The serum DCP levels (320±3532mAU/mL) and tumor size (18.4±9.0mm) of patients with hypervascular HCC were significantly greater than those with hypovascular HCC (38.7±80mAU/mL and 14.6±5.2mm, P
AB - Background and Aim: Hepatocellular carcinoma (HCC) is a hypervascular tumor, and angiogenesis plays an important role in its development. Previously, we demonstrated that des-γ-carboxyl prothrombin (DCP) promotes both cell proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inducing the autophosphorylation of kinase insert domain receptor (KDR). In the present study, DCP-associated tumor angiogenesis was assessed by comparing hypovascular and common hypervascular HCC. Methods: The solitary HCCs of 827 patients were classified into two groups according to the tumor density at the arterial phase of a dynamic computed tomography scan; the initial clinical data of patients with the hyper- and hypovascular types were compared. The HCC tissues from 95 tumors were analyzed by immunohistochemical staining for DCP and phosphorylated KDR, and intratumoral microvessel density (MVD) was analyzed to evaluate microvessel angiogenesis. Results: The serum DCP levels (320±3532mAU/mL) and tumor size (18.4±9.0mm) of patients with hypervascular HCC were significantly greater than those with hypovascular HCC (38.7±80mAU/mL and 14.6±5.2mm, P
KW - Des-γ-carboxyl prothrombin
KW - Hepatocellular carcinoma
KW - Intratumoral microvessel density
KW - Kinase insert domain receptor
UR - http://www.scopus.com/inward/record.url?scp=84866550659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866550659&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.2012.07173.x
DO - 10.1111/j.1440-1746.2012.07173.x
M3 - Article
C2 - 22554292
AN - SCOPUS:84866550659
VL - 27
SP - 1602
EP - 1608
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 10
ER -