p-Methoxybenzyl, diphenylmethyl, and tert-butyl esters were deprotected by gentle heating in phenol. This method of ester cleavage played an important role in β-lactam synthesis. The mechanism of the reaction is believed to involve a proton relay through a hydrogen-bonded phenolic matrix.
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Organic Chemistry