TY - JOUR
T1 - Depression of long term potentiation in gerbil hippocampus following postischemic hypothermia
AU - Miyamoto, Osamu
AU - Nakamura, Takehiro
AU - Yamagami, Shin ich
AU - Negi, Tetsuro
AU - Tokuda, Masaaki
AU - Matsui, Hideki
AU - Itano, Toshifumi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science. The authors wish to thank Dr. Yun-Fei Lu for helpful suggestions for a LTP experiment.
PY - 2000/8/4
Y1 - 2000/8/4
N2 - To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-D-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°Cx4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. Copyright (C) 2000 Elsevier Science B.V.
AB - To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-D-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°Cx4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. Copyright (C) 2000 Elsevier Science B.V.
KW - Gerbil
KW - Hippocampus
KW - Immunohistochemistry
KW - Long term potentiation
KW - N-Methyl-D-aspartate receptor 1
KW - Postischemic hypothermia
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U2 - 10.1016/S0006-8993(00)02521-X
DO - 10.1016/S0006-8993(00)02521-X
M3 - Article
C2 - 10915827
AN - SCOPUS:0034604745
VL - 873
SP - 168
EP - 172
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -