Abstract
To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-D-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°Cx4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. Copyright (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 168-172 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 873 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 4 2000 |
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Keywords
- Gerbil
- Hippocampus
- Immunohistochemistry
- Long term potentiation
- N-Methyl-D-aspartate receptor 1
- Postischemic hypothermia
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Depression of long term potentiation in gerbil hippocampus following postischemic hypothermia. / Miyamoto, Osamu; Nakamura, Takehiro; Yamagami, Shin ich; Negi, Tetsuro; Tokuda, Masaaki; Matsui, Hideki; Itano, Toshifumi.
In: Brain Research, Vol. 873, No. 1, 04.08.2000, p. 168-172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression of long term potentiation in gerbil hippocampus following postischemic hypothermia
AU - Miyamoto, Osamu
AU - Nakamura, Takehiro
AU - Yamagami, Shin ich
AU - Negi, Tetsuro
AU - Tokuda, Masaaki
AU - Matsui, Hideki
AU - Itano, Toshifumi
PY - 2000/8/4
Y1 - 2000/8/4
N2 - To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-D-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°Cx4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. Copyright (C) 2000 Elsevier Science B.V.
AB - To investigate the mechanism of chronic cell death following postischemic hypothermia, the change of N-methyl-D-aspartate receptor (NMDAR) were examined by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in the CA1 subfield of the gerbil hippocampus. At 1 week following postischemic hypothermia (32°Cx4 h), all CA1 neurons survived; however, immunoreactivity of NMDAR1 increased in neuronal perikarya whereas decreased in dendrites in the CA1 neurons. The abnormality was still observed in remaining CA1 neurons at 1 month after hypothermia. LTP was also significantly depressed at 1 week after hypothermia. These results suggest that some abnormalities in the glutamate receptor may be caused by ischemia; such abnormality would persist in spite of hypothermia treatment, resulting in the depression of LTP. Copyright (C) 2000 Elsevier Science B.V.
KW - Gerbil
KW - Hippocampus
KW - Immunohistochemistry
KW - Long term potentiation
KW - N-Methyl-D-aspartate receptor 1
KW - Postischemic hypothermia
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UR - http://www.scopus.com/inward/citedby.url?scp=0034604745&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(00)02521-X
DO - 10.1016/S0006-8993(00)02521-X
M3 - Article
C2 - 10915827
AN - SCOPUS:0034604745
VL - 873
SP - 168
EP - 172
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -