@article{accf52ca42134ba79556b01b413a35e3,
title = "Depletion of CD38-positive regulatory T cells by anti-CD38 monoclonal antibodies induces a durable response to SARS-CoV-2 vaccination in patients with plasma cell dyscrasia",
abstract = "This study reports the relationship between CD38+ regulatory T cells (Tregs) and messenger RNA coronavirus disease 2019 (mRNA-COVID-19) vaccination in 60 patients with plasma cell dyscrasia. Patients treated with anti-CD38 monoclonal antibodies (mAbs) had significantly lower CD38+ Tregs than those not treated (0.9 vs. 13.2/μl). Late-responders, whose antibody titres increased from weeks 4–12 after the second vaccination, had significantly lower CD38+ Treg counts than non-late-responders (2.5 vs. 10.3/μl). Antibody titres in patients with lower CD38+ Treg levels were maintained from weeks 4–12 but decreased in those with higher CD38+ Treg levels. Therefore, depletion of CD38+ Tregs by anti-CD38 mAbs may induce a durable response to mRNA-COVID-19 vaccination.",
keywords = "anti-CD38 monoclonal antibody, coronavirus disease 2019 (COVID-19), multiple myeloma, regulatory T cell, vaccines",
author = "Toshiki Terao and Takashi Naduka and Daisuke Ikeda and Ami Fukumoto and Yuya Kamura and Ayumi Kuzume and Rikako Tabata and Takafumi Tsushima and Daisuke Miura and Kentaro Narita and Masami Takeuchi and Kosei Matsue",
note = "Funding Information: The authors would like to thank the patients with haematological malignancies, their families, and the medical staff of the Department of Haematology of Kameda Medical Center. We also would like to thank Eri Suzuki, R.N. (assistant staff of Department of Haematology) for data collection, Yuka Umezawa, M.T., Masahiro Doi., M.T., Kazuki Ueno, M.T., Hatsune Yanagida, M.T., and Harumi Ishikura, M.T. (Department of Laboratory Medicine) for antibody measurement, and Dr Akihiro Kitadate, MD, PhD. (Department of Haematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan) for critical review of the manuscript. We also thank Editage (https://www.editage.jp/) for English language editing. Publisher Copyright: {\textcopyright} 2022 British Society for Haematology and John Wiley & Sons Ltd.",
year = "2022",
month = may,
doi = "10.1111/bjh.18079",
language = "English",
volume = "197",
pages = "417--421",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",
}
