Dental sedation for patients with intellectual disability: A prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol

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Study Objective: To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. Design: Single-center, prospective, randomized clinical trial. Setting: Academic outpatient clinic. Subjects: 40 ASA physical status 1 and 2 patients with intellectual disability. Interventions: Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. Measurements: The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. Main Results: BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. Conclusion: Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.

Original languageEnglish
Pages (from-to)636-642
Number of pages7
JournalJournal of Clinical Anesthesia
Issue number8
Publication statusPublished - Dec 2011



  • Bispectral index
  • Dental treatments
  • Intellectual disability
  • Intravenous sedation
  • Target-controlled infusion

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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