Dendritic changes in the spinal dorsal horn following transection of a peripheral nerve

Tomosada Sugimoto, Stephen Gobel

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

In an attempt to examine the morphologic changes which take place in the spinal dorsal horn as a consequence of peripheral nerve injury, the superficial radial nerve was cut and prevented from regenerating in adult cats. In laminae I-V of the 7th cervical segment of spinal dorsal horn at 2 weeks, 1 and 2 months following transection, small and medium-sized dendritic shafts developed membrane-bounded cavities. These cavities varied in number and size in each dendrite and were sometimes connected to the agranular reticulum. Large cavities often hollowed out a dendrite, leaving little remaining cytoplasm between the cavity membrane and the plasma membrane. Small and large cavities were frequently found open to the intercellular space. Synaptic glomeruli showed a loss of small dendrites with empty scalloped depressions in the central axonal endings of these structures left exposed to enlarged intercellular spaces. In addition, clusters of many enlarged oval or irregular intercellular spaces were found in the neuropil where many cavitated dendrites were observed. At least some of these intercellular spaces were thought to be derived from the loss of dendrites. From these observations we conclude that small and medium-sized dendrites involute through cavitation and eventually disappear from the spinal dorsal horn when primary input is disturbed by transection of peripheral sensory nerves.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalBrain Research
Volume321
Issue number2
DOIs
Publication statusPublished - Nov 12 1984
Externally publishedYes

Fingerprint

Dendrites
Peripheral Nerves
Extracellular Space
Radial Nerve
Peripheral Nerve Injuries
Reticulum
Neuropil
Membranes
Spinal Cord Dorsal Horn
Cytoplasm
Cats
Cell Membrane

Keywords

  • dendrite
  • electron microscope
  • peripheral nerve injury
  • spinal dorsal horn
  • transsynaptic effect

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dendritic changes in the spinal dorsal horn following transection of a peripheral nerve. / Sugimoto, Tomosada; Gobel, Stephen.

In: Brain Research, Vol. 321, No. 2, 12.11.1984, p. 199-208.

Research output: Contribution to journalArticle

Sugimoto, Tomosada ; Gobel, Stephen. / Dendritic changes in the spinal dorsal horn following transection of a peripheral nerve. In: Brain Research. 1984 ; Vol. 321, No. 2. pp. 199-208.
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