Abstract
Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
| Original language | English |
|---|---|
| Pages (from-to) | 369-375 |
| Number of pages | 7 |
| Journal | Advances in experimental medicine and biology |
| Volume | 255 |
| Publication status | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Matsui, H., Itano, T., Etoh, S., Tokuda, M., Wang, J. H., & Hatase, O. (1989). Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies. Advances in experimental medicine and biology, 255, 369-375.