Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

H. Matsui; T. Itano; S. Etoh; M. Tokuda; J. H. Wang; O. Hatase

Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

H. Matsui, T. Itano, S. Etoh, M. Tokuda, J. H. Wang, O. Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.

Original language	English
Pages (from-to)	369-375
Number of pages	7
Journal	Advances in experimental medicine and biology
Volume	255
Publication status	Published - 1989

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.",

abstract = "Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.",

author = "H. Matsui and T. Itano and S. Etoh and M. Tokuda and Wang, {J. H.} and O. Hatase",

year = "1989",

language = "English",

volume = "255",

pages = "369--375",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

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T1 - Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

AU - Matsui, H.

AU - Itano, T.

AU - Etoh, S.

AU - Tokuda, M.

AU - Wang, J. H.

AU - Hatase, O.

PY - 1989

Y1 - 1989

N2 - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.

AB - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.

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VL - 255

SP - 369

EP - 375

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -

Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

Abstract

ASJC Scopus subject areas

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