Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

H. Matsui, T. Itano, S. Etoh, M. Tokuda, J. H. Wang, O. Hatase

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalAdvances in experimental medicine and biology
Volume255
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.'. Together they form a unique fingerprint.

  • Cite this