Abstract
Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
| Original language | English |
|---|---|
| Pages (from-to) | 369-375 |
| Number of pages | 7 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 255 |
| Publication status | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies. / Matsui, Hideki; Itano, T.; Etoh, S.; Tokuda, M.; Wang, J. H.; Hatase, O.
In: Advances in Experimental Medicine and Biology, Vol. 255, 1989, p. 369-375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.
AU - Matsui, Hideki
AU - Itano, T.
AU - Etoh, S.
AU - Tokuda, M.
AU - Wang, J. H.
AU - Hatase, O.
PY - 1989
Y1 - 1989
N2 - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
AB - Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
UR - http://www.scopus.com/inward/record.url?scp=0024846803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024846803&partnerID=8YFLogxK
M3 - Article
C2 - 2559600
AN - SCOPUS:0024846803
VL - 255
SP - 369
EP - 375
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -