Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies.

Hideki Matsui, T. Itano, S. Etoh, M. Tokuda, J. H. Wang, O. Hatase

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume255
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Calcineurin
Rats
Brain
Demonstrations
Monoclonal Antibodies
Neocortex
Thalamus
Metal ions
Zinc
Hippocampus
Metals
Ions
calcineurin phosphatase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies. / Matsui, Hideki; Itano, T.; Etoh, S.; Tokuda, M.; Wang, J. H.; Hatase, O.

In: Advances in Experimental Medicine and Biology, Vol. 255, 1989, p. 369-375.

Research output: Contribution to journalArticle

Matsui, Hideki ; Itano, T. ; Etoh, S. ; Tokuda, M. ; Wang, J. H. ; Hatase, O. / Demonstration of different regional distributions of calcineurin subunits using monoclonal antibodies. In: Advances in Experimental Medicine and Biology. 1989 ; Vol. 255. pp. 369-375.
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