Abstract
Immunohistochemical localizations of calcineurin subunits A (60 KDa) and B (20 KDa) were examined in a rat brain using subunit specific monoclonal antibodies. The immunoreactivity of the subunit A was abundant in the hippocampus, in the striatum, and in the thalamus, but weak in the neocortex. On the contrary, the immunoreactivity of the subunit B was more abundant in the cortex, and it was more ubiquitous than subunit A. The distribution of subunit A in the rat brain very well agreed with that of zinc, which is an intrinsic metal ion and a potent inhibitor of calcineurin phosphatase.
Original language | English |
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Pages (from-to) | 369-375 |
Number of pages | 7 |
Journal | Advances in experimental medicine and biology |
Volume | 255 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)