Demonstration of antigen-specific immune response against Streptococcus sanguis

Norihisa Ishii, Emiko Isogai, Yuko Yamakawa, Hiroshi Nakajima, Shigeaki Ohno, Hiroshi Isogai, Shunji Hayashi, Kenji Yokota, Keiji Oguma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The genetic control of Streptococcus sanguis antigen response was studied. Mice sensitized with inactivated S. sanguis organisms antigen-injected at the base of the tail developed footpad swelling. Those with an I-Ak,q,r region of H-2 showed a strong footpad response, whereas those with an I-Ab,d,s region showed a weak response to S. sanguis cell wall antigen. Footpad response was mediated by CD4+, 8- T cells by using in vitro monoclonal antibody treatment. Similar evidence of genetic control was obtained with an in vitro T cell proliferation assay. However, quantitation of antibodies against S. sanguis showed that antibody production was not controlled by H-2. These results indicated that both in vivo footpad swelling and in vitro T cell proliferation responses were functions of helper (CD3+, 4+, 8-) T cells and controlled by the I-A region of H-2.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalJournal of Dermatological Science
Volume5
Issue number3
DOIs
Publication statusPublished - 1993

Fingerprint

Streptococcus sanguis
T-cells
Histocompatibility Antigens Class II
Demonstrations
T-Lymphocytes
Antigens
Cell proliferation
Swelling
Cell Proliferation
Antibodies
Cell Wall
Antibody Formation
Tail
Assays
Monoclonal Antibodies
Cells
In Vitro Techniques

Keywords

  • Antibody production
  • Footpad swelling
  • Genetic control
  • Helper T cells
  • Streptococcus sanguis
  • T cell proliferation

ASJC Scopus subject areas

  • Dermatology

Cite this

Ishii, N., Isogai, E., Yamakawa, Y., Nakajima, H., Ohno, S., Isogai, H., ... Oguma, K. (1993). Demonstration of antigen-specific immune response against Streptococcus sanguis. Journal of Dermatological Science, 5(3), 182-189. https://doi.org/10.1016/0923-1811(93)90765-H

Demonstration of antigen-specific immune response against Streptococcus sanguis. / Ishii, Norihisa; Isogai, Emiko; Yamakawa, Yuko; Nakajima, Hiroshi; Ohno, Shigeaki; Isogai, Hiroshi; Hayashi, Shunji; Yokota, Kenji; Oguma, Keiji.

In: Journal of Dermatological Science, Vol. 5, No. 3, 1993, p. 182-189.

Research output: Contribution to journalArticle

Ishii, N, Isogai, E, Yamakawa, Y, Nakajima, H, Ohno, S, Isogai, H, Hayashi, S, Yokota, K & Oguma, K 1993, 'Demonstration of antigen-specific immune response against Streptococcus sanguis', Journal of Dermatological Science, vol. 5, no. 3, pp. 182-189. https://doi.org/10.1016/0923-1811(93)90765-H
Ishii, Norihisa ; Isogai, Emiko ; Yamakawa, Yuko ; Nakajima, Hiroshi ; Ohno, Shigeaki ; Isogai, Hiroshi ; Hayashi, Shunji ; Yokota, Kenji ; Oguma, Keiji. / Demonstration of antigen-specific immune response against Streptococcus sanguis. In: Journal of Dermatological Science. 1993 ; Vol. 5, No. 3. pp. 182-189.
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