Demonstration of antigen-specific immune response against Streptococcus sanguis

Norihisa Ishii, Emiko Isogai, Yuko Yamakawa, Hiroshi Nakajima, Shigeaki Ohno, Hiroshi Isogai, Shunji Hayashi, Kenji Yokota, Keiji Oguma

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The genetic control of Streptococcus sanguis antigen response was studied. Mice sensitized with inactivated S. sanguis organisms antigen-injected at the base of the tail developed footpad swelling. Those with an I-Ak,q,r region of H-2 showed a strong footpad response, whereas those with an I-Ab,d,s region showed a weak response to S. sanguis cell wall antigen. Footpad response was mediated by CD4+, 8- T cells by using in vitro monoclonal antibody treatment. Similar evidence of genetic control was obtained with an in vitro T cell proliferation assay. However, quantitation of antibodies against S. sanguis showed that antibody production was not controlled by H-2. These results indicated that both in vivo footpad swelling and in vitro T cell proliferation responses were functions of helper (CD3+, 4+, 8-) T cells and controlled by the I-A region of H-2.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalJournal of dermatological science
Issue number3
Publication statusPublished - Jun 1993


  • Antibody production
  • Footpad swelling
  • Genetic control
  • Helper T cells
  • Streptococcus sanguis
  • T cell proliferation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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