Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory ganglia

H. Ichikawa, S. Schulz, V. Höllt, T. Sugimoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Immunohistochemistry for delta-opioid receptor (DOR) was performed on the rat cranial sensory ganglia. The immunoreactivity was detected in 16%, 19% and 11% of neurons in the trigeminal, jugular and petrosal ganglia, respectively. The nodose ganglion was devoid of such neurons. DOR-immunoreactive (IR) neurons were mostly small to medium-sized (trigeminal, range = 62-851 μm2, mean ± SD = 359 ± 175 μm2; jugular, range = 120-854 μm2, mean ± SD = 409 ± 196 μm2; petrosal, range = 167-1146 μm2, mean ± SD = 423 ± 233 μm2). Double immunofluorescence method revealed that all DOR-IR neurons were also immunoreactive for calcitonin gene-related peptide. The cutaneous and mucosal epithelia in the oro-facial region, tooth pulp, taste bud and carotid body were innervated by DOR-IR nerve fibers. In the brainstem, IR nerve terminals were located in the superficial medullary dorsal horn and dorsomedial part of the subnucleus oralis as well as the solitary tract nucleus. The present study suggests that DOR-IR neurons may be associated with nociceptive and/or chemoreceptive function in the cranial sensory ganglia.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalBrain Research
Volume1043
Issue number1-2
DOIs
Publication statusPublished - May 10 2005

Fingerprint

Sensory Ganglia
delta Opioid Receptor
Neurons
Neck
Nodose Ganglion
Taste Buds
Carotid Body
Solitary Nucleus
Calcitonin Gene-Related Peptide
Nerve Fibers
Ganglia
Brain Stem
Fluorescent Antibody Technique
Tooth
Epithelium
Immunohistochemistry
Skin

Keywords

  • Calcitonin gene-related peptide
  • Delta-opioid receptor
  • Immunohistochemistry
  • Jugular ganglion
  • Petrosal ganglion
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory ganglia. / Ichikawa, H.; Schulz, S.; Höllt, V.; Sugimoto, T.

In: Brain Research, Vol. 1043, No. 1-2, 10.05.2005, p. 225-230.

Research output: Contribution to journalArticle

Ichikawa, H, Schulz, S, Höllt, V & Sugimoto, T 2005, 'Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory ganglia', Brain Research, vol. 1043, no. 1-2, pp. 225-230. https://doi.org/10.1016/j.brainres.2005.02.041
Ichikawa, H. ; Schulz, S. ; Höllt, V. ; Sugimoto, T. / Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory ganglia. In: Brain Research. 2005 ; Vol. 1043, No. 1-2. pp. 225-230.
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