Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants

Yoshiyuki Murata; Ken Ichi Osaki; Yasuaki Shimoishi; Naomichi Baba; Mikiro Tada

doi:10.1271/bbb.68.743

Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants

Yoshiyuki Murata, Ken Ichi Osaki, Yasuaki Shimoishi, Naomichi Baba, Mikiro Tada

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (log P) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.

Original language	English
Pages (from-to)	743-745
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	68
Issue number	3
DOIs	https://doi.org/10.1271/bbb.68.743
Publication status	Published - Mar 2004

Keywords

4,7,10,13,16,19-docosahexaenoic acid (DHA)
Antioxidant
Flavonoid
Liposome
γ-ray

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants",

abstract = "Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (log P) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.",

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author = "Yoshiyuki Murata and Osaki, {Ken Ichi} and Yasuaki Shimoishi and Naomichi Baba and Mikiro Tada",

year = "2004",

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T1 - Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants

AU - Murata, Yoshiyuki

AU - Osaki, Ken Ichi

AU - Shimoishi, Yasuaki

AU - Baba, Naomichi

AU - Tada, Mikiro

PY - 2004/3

Y1 - 2004/3

N2 - Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (log P) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.

AB - Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (log P) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.

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KW - Antioxidant

KW - Flavonoid

KW - Liposome

KW - γ-ray

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Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants

Abstract

Keywords

ASJC Scopus subject areas

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