Degradation of ethyl docosahexaenoate by γ-ray irradiation and suppression of this degradation by antioxidants

Yoshiyuki Murata, Ken Ichi Osaki, Yasuaki Shimoishi, Naomichi Baba, Mikiro Tada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with γ rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (log P) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.

Original languageEnglish
Pages (from-to)743-745
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume68
Issue number3
DOIs
Publication statusPublished - Mar 1 2004

Keywords

  • 4,7,10,13,16,19-docosahexaenoic acid (DHA)
  • Antioxidant
  • Flavonoid
  • Liposome
  • γ-ray

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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