Degeneration of skeletal and cardiac muscles in c-myb transgenic mice

Yasuhide Furuta, Shinichi Aizawa, Yoko Suda, Yoji Ikawa, Hideki Nakasgoshi, Yukio Nishina, Shunsuke Ishii

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In order to reveal cellular processes sensitive to abnormal c-myb expression in vivo, transgenic mice were produced by introducing the c-myb nuclear proto-oncogene under the ubiquitous transcriptional regulatory unit of the cytoplasmic β-actin gene. Expression of c-myb in thymus did not cause apparent abnormality, but the mice unexpectedly developed degenerative abnormalities in skeletal and cardiac muscles; this occurred predominantly in males. Expression of c-myb in skeletal muscle was correlated with an inflammation of muscle and was accompanied by vacuolar degeneration of muscle fibres, their regeneration, and lymphocyte infiltration. The identical pathological progression in cardiac muscle was associated with cardiomegaly.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalTransgenic Research
Volume2
Issue number4
DOIs
Publication statusPublished - Jul 1 1993
Externally publishedYes

Keywords

  • cardiomegaly
  • muscle degeneration
  • myb
  • polymyositis
  • transgenic mice

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Agronomy and Crop Science
  • Genetics

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  • Cite this

    Furuta, Y., Aizawa, S., Suda, Y., Ikawa, Y., Nakasgoshi, H., Nishina, Y., & Ishii, S. (1993). Degeneration of skeletal and cardiac muscles in c-myb transgenic mice. Transgenic Research, 2(4), 199-207. https://doi.org/10.1007/BF01977350