Degeneration of skeletal and cardiac muscles in c-myb transgenic mice

Yasuhide Furuta, Shinichi Aizawa, Yoko Suda, Yoji Ikawa, Hideki Nakagoshi, Yukio Nishina, Shunsuke Ishii

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In order to reveal cellular processes sensitive to abnormal c-myb expression in vivo, transgenic mice were produced by introducing the c-myb nuclear proto-oncogene under the ubiquitous transcriptional regulatory unit of the cytoplasmic β-actin gene. Expression of c-myb in thymus did not cause apparent abnormality, but the mice unexpectedly developed degenerative abnormalities in skeletal and cardiac muscles; this occurred predominantly in males. Expression of c-myb in skeletal muscle was correlated with an inflammation of muscle and was accompanied by vacuolar degeneration of muscle fibres, their regeneration, and lymphocyte infiltration. The identical pathological progression in cardiac muscle was associated with cardiomegaly.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalTransgenic Research
Volume2
Issue number4
DOIs
Publication statusPublished - Jul 1993
Externally publishedYes

Fingerprint

myocardium
Transgenic Mice
skeletal muscle
Myocardium
Skeletal Muscle
myb Genes
genetically modified organisms
proto-oncogenes
Muscles
mice
Cardiomegaly
muscle fibers
Thymus Gland
actin
Actins
Regeneration
lymphocytes
inflammation
Lymphocytes
Inflammation

Keywords

  • cardiomegaly
  • muscle degeneration
  • myb
  • polymyositis
  • transgenic mice

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics
  • Biotechnology
  • Plant Science
  • Food Science

Cite this

Furuta, Y., Aizawa, S., Suda, Y., Ikawa, Y., Nakagoshi, H., Nishina, Y., & Ishii, S. (1993). Degeneration of skeletal and cardiac muscles in c-myb transgenic mice. Transgenic Research, 2(4), 199-207. https://doi.org/10.1007/BF01977350

Degeneration of skeletal and cardiac muscles in c-myb transgenic mice. / Furuta, Yasuhide; Aizawa, Shinichi; Suda, Yoko; Ikawa, Yoji; Nakagoshi, Hideki; Nishina, Yukio; Ishii, Shunsuke.

In: Transgenic Research, Vol. 2, No. 4, 07.1993, p. 199-207.

Research output: Contribution to journalArticle

Furuta, Y, Aizawa, S, Suda, Y, Ikawa, Y, Nakagoshi, H, Nishina, Y & Ishii, S 1993, 'Degeneration of skeletal and cardiac muscles in c-myb transgenic mice', Transgenic Research, vol. 2, no. 4, pp. 199-207. https://doi.org/10.1007/BF01977350
Furuta, Yasuhide ; Aizawa, Shinichi ; Suda, Yoko ; Ikawa, Yoji ; Nakagoshi, Hideki ; Nishina, Yukio ; Ishii, Shunsuke. / Degeneration of skeletal and cardiac muscles in c-myb transgenic mice. In: Transgenic Research. 1993 ; Vol. 2, No. 4. pp. 199-207.
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