Defining the Added Value of 99mTc-MIBI SPECT/CT to Conventional Cross-Sectional Imaging in the Characterization of Enhancing Solid Renal Masses

Sara Sheikhbahaei, Christopher S. Jones, Kristin K. Porter, Steven P. Rowe, Michael A. Gorin, Alex S. Baras, Phillip M. Pierorazio, Mark W. Ball, Takahiro Higuchi, Pamela T. Johnson, Lilja B. Solnes, Jonathan I. Epstein, Mohamad E. Allaf, Mehrbod S. Javadi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose This study investigates whether the addition of preoperative 99mTc-MIBI SPECT/CT can increase the degree of diagnostic confidence in the differentiation of benign from malignant enhancing renal masses. Patients and Methods Patients were recruited as part of an institutional review board-approved prospective clinical trial. Forty-eight patients with clinical stage T1 solid renal masses who underwent a 99mTc-MIBI SPECT/CT before partial or radical nephrectomy were evaluated. Conventional CT and MRI, which were approximately performed within 8 weeks before 99mTc-MIBI, were retrospectively retrieved. Based on a 5-point scale (1 = definitely benign, 5 = definitely malignant), 2 blinded readers recorded their degree of confidence for each lesion using conventional imaging before and after reviewing the 99mTc-MIBI uptake ratios. Surgical pathology was considered as the reference standard. Results Additional review of 99mTc-MIBI SPECT/CT uptake ratios increased diagnostic confidence in the differentiation of solid renal masses in 14/48 lesions (29.2%). In 9 lesions, the addition of 99mTc-MIBI changed the initial confidence levels of malignancy toward benign diagnosis. Postsurgical pathology confirmed the diagnosis of benign histology (oncocytoma/hybrid oncocytic-chromophobe tumors) in 7 and chromophobe renal cell carcinoma (behave as indolent) in 2 of these lesions. 99mTc-MIBI increased the confidence level toward malignancy in 5 cases; all were confirmed as RCC on surgical pathology. The area under the receiver operative characteristic curve was 0.60 for conventional imaging alone and 0.85 after reviewing 99mTc-MIBI (P for difference = 0.03). Conclusions Preoperative 99mTc-MIBI SPECT/CT enhances the performance of conventional imaging, improving the characterization of benign histologies and lowering the possibility of misclassification.

Original languageEnglish
Pages (from-to)e188-e193
JournalClinical Nuclear Medicine
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 1 2017
Externally publishedYes

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Kidney
Surgical Pathology
Histology
Oxyphilic Adenoma
Neoplasms
Research Ethics Committees
Nephrectomy
Renal Cell Carcinoma
Clinical Trials
Pathology
Single Photon Emission Computed Tomography Computed Tomography

Keywords

  • Tc-MIBI
  • cross-sectional imaging
  • renal mass
  • SPECT/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Defining the Added Value of 99mTc-MIBI SPECT/CT to Conventional Cross-Sectional Imaging in the Characterization of Enhancing Solid Renal Masses. / Sheikhbahaei, Sara; Jones, Christopher S.; Porter, Kristin K.; Rowe, Steven P.; Gorin, Michael A.; Baras, Alex S.; Pierorazio, Phillip M.; Ball, Mark W.; Higuchi, Takahiro; Johnson, Pamela T.; Solnes, Lilja B.; Epstein, Jonathan I.; Allaf, Mohamad E.; Javadi, Mehrbod S.

In: Clinical Nuclear Medicine, Vol. 42, No. 4, 01.04.2017, p. e188-e193.

Research output: Contribution to journalArticle

Sheikhbahaei, S, Jones, CS, Porter, KK, Rowe, SP, Gorin, MA, Baras, AS, Pierorazio, PM, Ball, MW, Higuchi, T, Johnson, PT, Solnes, LB, Epstein, JI, Allaf, ME & Javadi, MS 2017, 'Defining the Added Value of 99mTc-MIBI SPECT/CT to Conventional Cross-Sectional Imaging in the Characterization of Enhancing Solid Renal Masses', Clinical Nuclear Medicine, vol. 42, no. 4, pp. e188-e193. https://doi.org/10.1097/RLU.0000000000001534
Sheikhbahaei, Sara ; Jones, Christopher S. ; Porter, Kristin K. ; Rowe, Steven P. ; Gorin, Michael A. ; Baras, Alex S. ; Pierorazio, Phillip M. ; Ball, Mark W. ; Higuchi, Takahiro ; Johnson, Pamela T. ; Solnes, Lilja B. ; Epstein, Jonathan I. ; Allaf, Mohamad E. ; Javadi, Mehrbod S. / Defining the Added Value of 99mTc-MIBI SPECT/CT to Conventional Cross-Sectional Imaging in the Characterization of Enhancing Solid Renal Masses. In: Clinical Nuclear Medicine. 2017 ; Vol. 42, No. 4. pp. e188-e193.
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abstract = "Purpose This study investigates whether the addition of preoperative 99mTc-MIBI SPECT/CT can increase the degree of diagnostic confidence in the differentiation of benign from malignant enhancing renal masses. Patients and Methods Patients were recruited as part of an institutional review board-approved prospective clinical trial. Forty-eight patients with clinical stage T1 solid renal masses who underwent a 99mTc-MIBI SPECT/CT before partial or radical nephrectomy were evaluated. Conventional CT and MRI, which were approximately performed within 8 weeks before 99mTc-MIBI, were retrospectively retrieved. Based on a 5-point scale (1 = definitely benign, 5 = definitely malignant), 2 blinded readers recorded their degree of confidence for each lesion using conventional imaging before and after reviewing the 99mTc-MIBI uptake ratios. Surgical pathology was considered as the reference standard. Results Additional review of 99mTc-MIBI SPECT/CT uptake ratios increased diagnostic confidence in the differentiation of solid renal masses in 14/48 lesions (29.2{\%}). In 9 lesions, the addition of 99mTc-MIBI changed the initial confidence levels of malignancy toward benign diagnosis. Postsurgical pathology confirmed the diagnosis of benign histology (oncocytoma/hybrid oncocytic-chromophobe tumors) in 7 and chromophobe renal cell carcinoma (behave as indolent) in 2 of these lesions. 99mTc-MIBI increased the confidence level toward malignancy in 5 cases; all were confirmed as RCC on surgical pathology. The area under the receiver operative characteristic curve was 0.60 for conventional imaging alone and 0.85 after reviewing 99mTc-MIBI (P for difference = 0.03). Conclusions Preoperative 99mTc-MIBI SPECT/CT enhances the performance of conventional imaging, improving the characterization of benign histologies and lowering the possibility of misclassification.",
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AU - Porter, Kristin K.

AU - Rowe, Steven P.

AU - Gorin, Michael A.

AU - Baras, Alex S.

AU - Pierorazio, Phillip M.

AU - Ball, Mark W.

AU - Higuchi, Takahiro

AU - Johnson, Pamela T.

AU - Solnes, Lilja B.

AU - Epstein, Jonathan I.

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N2 - Purpose This study investigates whether the addition of preoperative 99mTc-MIBI SPECT/CT can increase the degree of diagnostic confidence in the differentiation of benign from malignant enhancing renal masses. Patients and Methods Patients were recruited as part of an institutional review board-approved prospective clinical trial. Forty-eight patients with clinical stage T1 solid renal masses who underwent a 99mTc-MIBI SPECT/CT before partial or radical nephrectomy were evaluated. Conventional CT and MRI, which were approximately performed within 8 weeks before 99mTc-MIBI, were retrospectively retrieved. Based on a 5-point scale (1 = definitely benign, 5 = definitely malignant), 2 blinded readers recorded their degree of confidence for each lesion using conventional imaging before and after reviewing the 99mTc-MIBI uptake ratios. Surgical pathology was considered as the reference standard. Results Additional review of 99mTc-MIBI SPECT/CT uptake ratios increased diagnostic confidence in the differentiation of solid renal masses in 14/48 lesions (29.2%). In 9 lesions, the addition of 99mTc-MIBI changed the initial confidence levels of malignancy toward benign diagnosis. Postsurgical pathology confirmed the diagnosis of benign histology (oncocytoma/hybrid oncocytic-chromophobe tumors) in 7 and chromophobe renal cell carcinoma (behave as indolent) in 2 of these lesions. 99mTc-MIBI increased the confidence level toward malignancy in 5 cases; all were confirmed as RCC on surgical pathology. The area under the receiver operative characteristic curve was 0.60 for conventional imaging alone and 0.85 after reviewing 99mTc-MIBI (P for difference = 0.03). Conclusions Preoperative 99mTc-MIBI SPECT/CT enhances the performance of conventional imaging, improving the characterization of benign histologies and lowering the possibility of misclassification.

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