Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis

Naoto Gotohda, Hiromi Iwagaki, Michitaka Ozaki, Taira Kinoshita, Masaru Konishi, Toshio Nakagohri, Shinichiro Takahashi, Shinya Saito, Takahito Yagi, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background/Aims: Liver regeneration after surgical resection is still a serious concern. The present study is designed to understand the relations between liver injury/regeneration and cytokines after hepatectomy with viral hepatitis. Methodology: Twenty-one consecutive patients undergoing liver resection were studied, which included two patients with biliary tract cancer, three patients with hepatic metastases from colorectal cancer, and sixteen patients with primary liver tumor. They were also divided into two groups according to the existence of chronic viral hepatitis: 10 patients with viral hepatitis and 11 patients without viral hepatitis. Results: Viral hepatitis reduced pre-operative liver function (ICG-R15 and platelet count) with raised levels of sFas. Interestingly, this also reduced postoperative surge of IL-6, but not HGF, though they were equally at basal levels pre-operatively. Recovery of liver size, calculated with resected liver mass and volumetry with CT scan, was deteriorated in liver with viral hepatitis, but any difference of postoperative liver damage was observed between two groups. Conclusions: Viral infection, somehow, increased sFas level pre-operatively, but does not influence the post-operative liver injury. Deficient response of IL-6, but not HGF, may be a major cause for poor liver regeneration after hepatectomy in patients with viral hepatitis independent from liver injury.

Original languageEnglish
Pages (from-to)1439-1444
Number of pages6
JournalHepato-Gastroenterology
Volume55
Issue number85
Publication statusPublished - Jul 2008

Keywords

  • Hepatocyte growth factor
  • Interleukin-6
  • Liver regeneration
  • Soluble interleukin-6 receptor
  • Viral hepatitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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