TY - JOUR
T1 - Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis
AU - Gotohda, Naoto
AU - Iwagaki, Hiromi
AU - Ozaki, Michitaka
AU - Kinoshita, Taira
AU - Konishi, Masaru
AU - Nakagohri, Toshio
AU - Takahashi, Shinichiro
AU - Saito, Shinya
AU - Yagi, Takahito
AU - Tanaka, Noriaki
PY - 2008/7
Y1 - 2008/7
N2 - Background/Aims: Liver regeneration after surgical resection is still a serious concern. The present study is designed to understand the relations between liver injury/regeneration and cytokines after hepatectomy with viral hepatitis. Methodology: Twenty-one consecutive patients undergoing liver resection were studied, which included two patients with biliary tract cancer, three patients with hepatic metastases from colorectal cancer, and sixteen patients with primary liver tumor. They were also divided into two groups according to the existence of chronic viral hepatitis: 10 patients with viral hepatitis and 11 patients without viral hepatitis. Results: Viral hepatitis reduced pre-operative liver function (ICG-R15 and platelet count) with raised levels of sFas. Interestingly, this also reduced postoperative surge of IL-6, but not HGF, though they were equally at basal levels pre-operatively. Recovery of liver size, calculated with resected liver mass and volumetry with CT scan, was deteriorated in liver with viral hepatitis, but any difference of postoperative liver damage was observed between two groups. Conclusions: Viral infection, somehow, increased sFas level pre-operatively, but does not influence the post-operative liver injury. Deficient response of IL-6, but not HGF, may be a major cause for poor liver regeneration after hepatectomy in patients with viral hepatitis independent from liver injury.
AB - Background/Aims: Liver regeneration after surgical resection is still a serious concern. The present study is designed to understand the relations between liver injury/regeneration and cytokines after hepatectomy with viral hepatitis. Methodology: Twenty-one consecutive patients undergoing liver resection were studied, which included two patients with biliary tract cancer, three patients with hepatic metastases from colorectal cancer, and sixteen patients with primary liver tumor. They were also divided into two groups according to the existence of chronic viral hepatitis: 10 patients with viral hepatitis and 11 patients without viral hepatitis. Results: Viral hepatitis reduced pre-operative liver function (ICG-R15 and platelet count) with raised levels of sFas. Interestingly, this also reduced postoperative surge of IL-6, but not HGF, though they were equally at basal levels pre-operatively. Recovery of liver size, calculated with resected liver mass and volumetry with CT scan, was deteriorated in liver with viral hepatitis, but any difference of postoperative liver damage was observed between two groups. Conclusions: Viral infection, somehow, increased sFas level pre-operatively, but does not influence the post-operative liver injury. Deficient response of IL-6, but not HGF, may be a major cause for poor liver regeneration after hepatectomy in patients with viral hepatitis independent from liver injury.
KW - Hepatocyte growth factor
KW - Interleukin-6
KW - Liver regeneration
KW - Soluble interleukin-6 receptor
KW - Viral hepatitis
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M3 - Article
C2 - 18795707
AN - SCOPUS:58149393047
VL - 55
SP - 1439
EP - 1444
JO - Hepato-Gastroenterology
JF - Hepato-Gastroenterology
SN - 0172-6390
IS - 85
ER -