Abstract
Environmental canalization is defined as a reduction in the effect of external environmental perturbations on a phenotype, while phenotypic plasticity is defined as the production of different phenotypes in alternative environments. These terms describe different aspects of the same phenomenon, that is, the sensitivity of the phenotype to the environment. Genetic regulation of the environmental sensitivity has been a central topic in the field of evolutionary biology. In this study, we performed deficiency screening to detect genomic regions with effects on the environmental sensitivity of Drosophila melanogaster sensory bristles. We used a collection of isogenic deficiency strains established by the DrosDel Project for screening. We screened 423 genomic deficiencies that encompassed approximately 63.6% of the entire D. melanogaster genome. We identified 29 genomic deficiencies showing significant effects on environmental sensitivity, suggesting that multiple genomic regions may influence phenotypic variation. We also found significant correlations among the effects of deficiencies on environmental sensitivity for different bristle traits, suggesting that the same genetic mechanism can regulate environmental sensitivity of multiple traits. Current high-resolution mapping will facilitate the examination of individual candidate genes using mutations or RNAi approaches in future studies.
| Original language | English |
|---|---|
| Pages (from-to) | 2878-2890 |
| Number of pages | 13 |
| Journal | Evolution |
| Volume | 66 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Developmental stability
- Environmental sensitivity
- Fluctuating asymmetry
- Isogenic deficiency strains
- Reaction norm
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Agricultural and Biological Sciences(all)
Cite this
Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of drosophila melanogaster. / Takahashi, Kazuo; Okada, Yasukazu; Teramura, Kouhei.
In: Evolution, Vol. 66, No. 9, 2012, p. 2878-2890.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of drosophila melanogaster
AU - Takahashi, Kazuo
AU - Okada, Yasukazu
AU - Teramura, Kouhei
PY - 2012
Y1 - 2012
N2 - Environmental canalization is defined as a reduction in the effect of external environmental perturbations on a phenotype, while phenotypic plasticity is defined as the production of different phenotypes in alternative environments. These terms describe different aspects of the same phenomenon, that is, the sensitivity of the phenotype to the environment. Genetic regulation of the environmental sensitivity has been a central topic in the field of evolutionary biology. In this study, we performed deficiency screening to detect genomic regions with effects on the environmental sensitivity of Drosophila melanogaster sensory bristles. We used a collection of isogenic deficiency strains established by the DrosDel Project for screening. We screened 423 genomic deficiencies that encompassed approximately 63.6% of the entire D. melanogaster genome. We identified 29 genomic deficiencies showing significant effects on environmental sensitivity, suggesting that multiple genomic regions may influence phenotypic variation. We also found significant correlations among the effects of deficiencies on environmental sensitivity for different bristle traits, suggesting that the same genetic mechanism can regulate environmental sensitivity of multiple traits. Current high-resolution mapping will facilitate the examination of individual candidate genes using mutations or RNAi approaches in future studies.
AB - Environmental canalization is defined as a reduction in the effect of external environmental perturbations on a phenotype, while phenotypic plasticity is defined as the production of different phenotypes in alternative environments. These terms describe different aspects of the same phenomenon, that is, the sensitivity of the phenotype to the environment. Genetic regulation of the environmental sensitivity has been a central topic in the field of evolutionary biology. In this study, we performed deficiency screening to detect genomic regions with effects on the environmental sensitivity of Drosophila melanogaster sensory bristles. We used a collection of isogenic deficiency strains established by the DrosDel Project for screening. We screened 423 genomic deficiencies that encompassed approximately 63.6% of the entire D. melanogaster genome. We identified 29 genomic deficiencies showing significant effects on environmental sensitivity, suggesting that multiple genomic regions may influence phenotypic variation. We also found significant correlations among the effects of deficiencies on environmental sensitivity for different bristle traits, suggesting that the same genetic mechanism can regulate environmental sensitivity of multiple traits. Current high-resolution mapping will facilitate the examination of individual candidate genes using mutations or RNAi approaches in future studies.
KW - Developmental stability
KW - Environmental sensitivity
KW - Fluctuating asymmetry
KW - Isogenic deficiency strains
KW - Reaction norm
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UR - http://www.scopus.com/inward/citedby.url?scp=85027924055&partnerID=8YFLogxK
U2 - 10.1111/j.1558-5646.2012.01636.x
DO - 10.1111/j.1558-5646.2012.01636.x
M3 - Article
C2 - 22946809
AN - SCOPUS:85027924055
VL - 66
SP - 2878
EP - 2890
JO - Evolution; international journal of organic evolution
JF - Evolution; international journal of organic evolution
SN - 0014-3820
IS - 9
ER -