Decreasing abdominal circumference is associated with improving estimated glomerular filtration rate (eGFR) with lifestyle modification in Japanese men: A pilot study

The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5 ± 8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r= -0.232, p = 0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men.