Decreased resting-state connections within the visuospatial attention-related network in advanced aging

Yujie Li, Chunlin Li, Qiong Wu, Zhihan Xu, Tomoko Kurata, Seiichiro Ohno, Susumu Kanazawa, Koji Abe, Jinglong Wu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Advanced aging is accompanied by a decline in visuospatial attention. Previous neuroimaging and electrophysiological studies have demonstrated dysfunction in specific brain areas related to visuospatial attention. However, it is still unclear how the functional connectivity between brain regions causes the decline of visuospatial attention. Here, we combined task and rest functional magnetic resonance imaging (fMRI) to investigate the age-dependent alterations of resting-state functional connectivity within the task-related network. Twenty-three young subjects and nineteen elderly subjects participated in this study, and a modified Posner paradigm was used to define the region of interest (ROI). Our results showed that a marked reduction in the number of connections occurred with age, but this effect was not uniform throughout the brain: while there was a significant loss of communication in the anterior portion of the brain and between the anterior and posterior cerebral cortices, communication in the posterior portion of the brain was preserved. Moreover, the older adults exhibited weakened resting-state functional connectivity between the supplementary motor area and left anterior insular cortex. These findings suggest that, the disrupted functional connectivity of the brain network for visuospatial attention that occurs during normal aging may underlie the decline in cognitive performance.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalNeuroscience Letters
Volume597
DOIs
Publication statusPublished - Jun 5 2015

Keywords

  • Aging effect
  • Functional magnetic resonance imaging (fMRI)
  • Posner task
  • Resting-state
  • Visual-spatial attention

ASJC Scopus subject areas

  • Neuroscience(all)

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