Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats

Takamitsu Komiyama, Keiichiro Nishida, Masanori Yorimitsu, Hideyuki Doi, Shinichi Miyazawa, Ai Kitamura, Aki Yoshida, Yoshihisa Nasu, Nobuhiro Abe, Toshihumi Ozaki

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Abstract

Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p <0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossification disturbance of the femoral head in SHR. Copyright

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalActa Medica Okayama
Volume60
Issue number3
Publication statusPublished - 2006

Fingerprint

Somatomedins
Inbred SHR Rats
Thigh
Osteogenesis
Vascular Endothelial Growth Factor A
Rats
Inbred WKY Rats
Serum
Growth Plate
Osteonecrosis
Chondrocytes
Cartilage
Incidence
Tissue

Keywords

  • Insulin like growth factor-1
  • Ossification disturbance
  • Osteonecrosis
  • Spontaneous hypertensive rats
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats. / Komiyama, Takamitsu; Nishida, Keiichiro; Yorimitsu, Masanori; Doi, Hideyuki; Miyazawa, Shinichi; Kitamura, Ai; Yoshida, Aki; Nasu, Yoshihisa; Abe, Nobuhiro; Ozaki, Toshihumi.

In: Acta Medica Okayama, Vol. 60, No. 3, 2006, p. 141-148.

Research output: Contribution to journalArticle

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AU - Nishida, Keiichiro

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AU - Doi, Hideyuki

AU - Miyazawa, Shinichi

AU - Kitamura, Ai

AU - Yoshida, Aki

AU - Nasu, Yoshihisa

AU - Abe, Nobuhiro

AU - Ozaki, Toshihumi

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