Abstract
The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.
| Original language | English |
|---|---|
| Pages (from-to) | 1907-1910 |
| Number of pages | 4 |
| Journal | Biochemical Pharmacology |
| Volume | 43 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 8 1992 |
| Externally published | Yes |
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- Pharmacology
Cite this
Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus). / Nakura, Hironori; Itoh, Susumu; Kusano, Hisashi; Ishizone, Hiroyuki; Imaoka, Susumu; Funae, Yoshihiko; Yokoi, Tsuyoshi; Kamataki, Tetsuya.
In: Biochemical Pharmacology, Vol. 43, No. 9, 08.05.1992, p. 1907-1910.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)
AU - Nakura, Hironori
AU - Itoh, Susumu
AU - Kusano, Hisashi
AU - Ishizone, Hiroyuki
AU - Imaoka, Susumu
AU - Funae, Yoshihiko
AU - Yokoi, Tsuyoshi
AU - Kamataki, Tetsuya
PY - 1992/5/8
Y1 - 1992/5/8
N2 - The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.
AB - The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.
UR - http://www.scopus.com/inward/record.url?scp=0026538414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026538414&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(92)90632-S
DO - 10.1016/0006-2952(92)90632-S
M3 - Article
C2 - 1596279
AN - SCOPUS:0026538414
VL - 43
SP - 1907
EP - 1910
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 9
ER -