Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)

Hironori Nakura; Susumu Itoh; Hisashi Kusano; Hiroyuki Ishizone; Susumu Imaoka; Yoshihiko Funae; Tsuyoshi Yokoi; Tetsuya Kamataki

doi:10.1016/0006-2952(92)90632-S

Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)

Hironori Nakura, Susumu Itoh, Hisashi Kusano, Hiroyuki Ishizone, Susumu Imaoka, Yoshihiko Funae, Tsuyoshi Yokoi, Tetsuya Kamataki

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Abstract

The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.

Original language	English
Pages (from-to)	1907-1910
Number of pages	4
Journal	Biochemical Pharmacology
Volume	43
Issue number	9
DOIs	https://doi.org/10.1016/0006-2952(92)90632-S
Publication status	Published - May 8 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(92)90632-S

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title = "Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)",

abstract = "The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.",

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T1 - Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)

AU - Nakura, Hironori

AU - Itoh, Susumu

AU - Kusano, Hisashi

AU - Ishizone, Hiroyuki

AU - Imaoka, Susumu

AU - Funae, Yoshihiko

AU - Yokoi, Tsuyoshi

AU - Kamataki, Tetsuya

PY - 1992/5/8

Y1 - 1992/5/8

N2 - The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.

AB - The effects of fasting on hepatic cytochrome P450 in the mature male house musk shrew, Suncus murinus (suncus), were studied by Western blot analyses and enzyme assays. The content of P450IIE protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which P450IIE protein was increased to 172% by fasting. These changes reflected on catalytic activities, such as aniline hydroxylase and N-nitrosodimethylamine demethylase activities, which were decreased to about 45% and 28%, respectively, of the control levels by fasting, while in fasting rats, the catalytic activities of these enzymes were 2-3-fold higher than in controls.

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Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)

Abstract

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