Decrease in histamine turnover in the brain of spontaneously hypertensive rats

Ryozo Oishi, Yoshinori Itoh, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalBrain Research
Volume343
Issue number1
DOIs
Publication statusPublished - Sep 16 1985

Keywords

  • blood pressure
  • histamine
  • l-histidine
  • spontaneously hypertensive rat
  • tele-methylhistamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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