Abstract
Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 180-183 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 343 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 16 1985 |
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Keywords
- blood pressure
- histamine
- l-histidine
- spontaneously hypertensive rat
- tele-methylhistamine
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Decrease in histamine turnover in the brain of spontaneously hypertensive rats. / Oishi, Ryozo; Itoh, Yoshinori; Nishibori, Masahiro; Saeki, Kiyomi.
In: Brain Research, Vol. 343, No. 1, 16.09.1985, p. 180-183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decrease in histamine turnover in the brain of spontaneously hypertensive rats
AU - Oishi, Ryozo
AU - Itoh, Yoshinori
AU - Nishibori, Masahiro
AU - Saeki, Kiyomi
PY - 1985/9/16
Y1 - 1985/9/16
N2 - Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.
AB - Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.
KW - blood pressure
KW - histamine
KW - l-histidine
KW - spontaneously hypertensive rat
KW - tele-methylhistamine
UR - http://www.scopus.com/inward/record.url?scp=0022379580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022379580&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(85)91175-8
DO - 10.1016/0006-8993(85)91175-8
M3 - Article
C2 - 4041852
AN - SCOPUS:0022379580
VL - 343
SP - 180
EP - 183
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -