Decrease in histamine turnover in the brain of spontaneously hypertensive rats

Ryozo Oishi; Yoshinori Itoh; Masahiro Nishibori; Kiyomi Saeki

doi:10.1016/0006-8993(85)91175-8

Decrease in histamine turnover in the brain of spontaneously hypertensive rats

Ryozo Oishi, Yoshinori Itoh, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journal › Article › peer-review

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Abstract

Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.

Original language	English
Pages (from-to)	180-183
Number of pages	4
Journal	Brain Research
Volume	343
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)91175-8
Publication status	Published - Sep 16 1985

Keywords

blood pressure
histamine
l-histidine
spontaneously hypertensive rat
tele-methylhistamine

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)91175-8

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abstract = "Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.",

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T1 - Decrease in histamine turnover in the brain of spontaneously hypertensive rats

AU - Oishi, Ryozo

AU - Itoh, Yoshinori

AU - Nishibori, Masahiro

AU - Saeki, Kiyomi

PY - 1985/9/16

Y1 - 1985/9/16

N2 - Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.

AB - Histamine (HA) turnover rate in the brain of spontaneously hypertensive rats (SHR) was determined by the accumulation of telemethylhistamine after pargyline treatment. The values in these SHR were lower than in the Wistar Kyoto rats, particularly in the hypothalamus and brainstem. However, chronic treatment with l-histidine had no effect on the development of hypertension in the SHR. The functional significance of the decreased HA turnover in SHR is discussed in relation to the pathogenesis of hypertension.

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KW - histamine

KW - l-histidine

KW - spontaneously hypertensive rat

KW - tele-methylhistamine

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