Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer's disease

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

There is a need to differentiate between patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from normal-aged controls (NC) in the field of clinical drug discovery. In this study, we developed a tactile angle discrimination system and examined whether the ability to discriminate tactile angle differed between patients with MCI and AD and the NC group. Thirty-seven subjects were divided into three groups: NC individuals (n=14); MCI patients (n=10); and probable AD patients (n=13). All subjects were asked to differentiate the relative sizes of the reference angle (60°) and one of eight comparison angles by passive touch. The accuracy of angle discrimination was measured and the discrimination threshold was calculated. We discovered that there were significant differences in the angle discrimination thresholds of AD patients compared to the NC group. Interestingly, we also found that ability to discriminate tactile angle of MCI patients were significantly lower than that of the NC group. This is the first study to report that patients with MCI and AD have substantial performance deficits in tactile angle discrimination compared to the NC individuals. This finding may provide a monitor and therapeutic approach in AD diagnosis and treatment.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalJournal of Alzheimer's Disease
Volume22
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Touch
Alzheimer Disease
Aptitude
Control Groups
Drug Discovery
Cognitive Dysfunction
Therapeutics

Keywords

  • Alzheimer's disease
  • cognitive function deficit
  • mild cognitive impairment
  • tactile angle discrimination
  • working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

@article{034f7ab2a418480882c9130ff09f50aa,
title = "Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer's disease",
abstract = "There is a need to differentiate between patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from normal-aged controls (NC) in the field of clinical drug discovery. In this study, we developed a tactile angle discrimination system and examined whether the ability to discriminate tactile angle differed between patients with MCI and AD and the NC group. Thirty-seven subjects were divided into three groups: NC individuals (n=14); MCI patients (n=10); and probable AD patients (n=13). All subjects were asked to differentiate the relative sizes of the reference angle (60°) and one of eight comparison angles by passive touch. The accuracy of angle discrimination was measured and the discrimination threshold was calculated. We discovered that there were significant differences in the angle discrimination thresholds of AD patients compared to the NC group. Interestingly, we also found that ability to discriminate tactile angle of MCI patients were significantly lower than that of the NC group. This is the first study to report that patients with MCI and AD have substantial performance deficits in tactile angle discrimination compared to the NC individuals. This finding may provide a monitor and therapeutic approach in AD diagnosis and treatment.",
keywords = "Alzheimer's disease, cognitive function deficit, mild cognitive impairment, tactile angle discrimination, working memory",
author = "Jiajia Yang and Takashi Ogasa and Yasuyuki Ohta and Koji Abe and Jinglong Wu",
year = "2010",
doi = "10.3233/JAD-2010-100723",
language = "English",
volume = "22",
pages = "225--234",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",

}

TY - JOUR

T1 - Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer's disease

AU - Yang, Jiajia

AU - Ogasa, Takashi

AU - Ohta, Yasuyuki

AU - Abe, Koji

AU - Wu, Jinglong

PY - 2010

Y1 - 2010

N2 - There is a need to differentiate between patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from normal-aged controls (NC) in the field of clinical drug discovery. In this study, we developed a tactile angle discrimination system and examined whether the ability to discriminate tactile angle differed between patients with MCI and AD and the NC group. Thirty-seven subjects were divided into three groups: NC individuals (n=14); MCI patients (n=10); and probable AD patients (n=13). All subjects were asked to differentiate the relative sizes of the reference angle (60°) and one of eight comparison angles by passive touch. The accuracy of angle discrimination was measured and the discrimination threshold was calculated. We discovered that there were significant differences in the angle discrimination thresholds of AD patients compared to the NC group. Interestingly, we also found that ability to discriminate tactile angle of MCI patients were significantly lower than that of the NC group. This is the first study to report that patients with MCI and AD have substantial performance deficits in tactile angle discrimination compared to the NC individuals. This finding may provide a monitor and therapeutic approach in AD diagnosis and treatment.

AB - There is a need to differentiate between patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from normal-aged controls (NC) in the field of clinical drug discovery. In this study, we developed a tactile angle discrimination system and examined whether the ability to discriminate tactile angle differed between patients with MCI and AD and the NC group. Thirty-seven subjects were divided into three groups: NC individuals (n=14); MCI patients (n=10); and probable AD patients (n=13). All subjects were asked to differentiate the relative sizes of the reference angle (60°) and one of eight comparison angles by passive touch. The accuracy of angle discrimination was measured and the discrimination threshold was calculated. We discovered that there were significant differences in the angle discrimination thresholds of AD patients compared to the NC group. Interestingly, we also found that ability to discriminate tactile angle of MCI patients were significantly lower than that of the NC group. This is the first study to report that patients with MCI and AD have substantial performance deficits in tactile angle discrimination compared to the NC individuals. This finding may provide a monitor and therapeutic approach in AD diagnosis and treatment.

KW - Alzheimer's disease

KW - cognitive function deficit

KW - mild cognitive impairment

KW - tactile angle discrimination

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=78650649905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650649905&partnerID=8YFLogxK

U2 - 10.3233/JAD-2010-100723

DO - 10.3233/JAD-2010-100723

M3 - Article

C2 - 20847416

AN - SCOPUS:78650649905

VL - 22

SP - 225

EP - 234

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -