De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report

Karina Cecília Panelli Santos, Hidenobu Matsuzaki, Teruhisa Unetsubo, Shimo Tsuyoshi, Hitoshi Nagatsuka, Jun Ichi Asaumi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.

Original languageEnglish
Pages (from-to)2679-2683
Number of pages5
JournalOncology Letters
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Dynamic magnetic resonance imaging
  • Myoepithelial carcinoma
  • Submandibular glands

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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